Grabar Sophie, Selinger-Leneman Hana, Abgrall Sophie, Pialoux Gilles, Weiss Laurence, Costagliola Dominique
INSERM U943, Bobigny, France.
AIDS. 2009 Jun 1;23(9):1163-9. doi: 10.1097/QAD.0b013e32832b44c8.
To estimate the prevalence and characteristics of long-term nonprogressor (LTNP) and HIV controller patients in a very large French cohort of HIV1-infected patients.
In the French Hospital Database on HIV [FHDH, Agence Nationale de Recherches sur le SIDA et les hépatites virales (ANRS) CO4], we selected patients who had been seen in 2005, who had been infected for more than 8 years, who were treatment-naive, and who remained asymptomatic. Patients with these characteristics then categorized as follows: LTNP (> or =8 years of HIV infection and CD4 cell nadir > or =500/microl), elite LTNP (> or =8 years of HIV infection, CD4 cell nadir > or =600/microl, and a positive CD4 slope), HIV controllers (>10 years of HIV infection with 90% of plasma viral load values < or =500 copies/ml), and elite controllers (same as HIV controllers, but with last plasma viral load value < or =50 copies/ml in 2005).
Among the 46 880 HIV1-infected patients followed in 2005 in the French Hospital Database on HIV, 0.4% (N = 202) were LTNP, 0.05% (N = 25) were elite LTNP, 0.22% (N = 101) were HIV controllers, and 0.15% (N = 69) were elite controllers. Ten elite LTNP patients (40%) were also HIV controllers, eight (32%) were elite controllers, and 60% had detectable plasma viral load (>50 copies/ml). Among the elite controllers, 32 (46%) were LTNP, eight (12%) were elite LTNP, and one-quarter had a last CD4 cell count less than 500/microl.
LTNP, elite LTNP, HIV controller, and elite controller patients are rare phenotypes. Elite LTNP patients are less frequent than HIV controllers. There is little overlap among the four subgroups of patients.
评估在一个非常大的法国HIV-1感染患者队列中，长期无进展者（LTNP）和HIV病毒控制者患者的患病率及特征。
在法国医院HIV数据库[FHDH，法国国家艾滋病和病毒性肝炎研究机构（ANRS）CO4]中，我们选取了2005年就诊、感染超过8年、未接受过治疗且无症状的患者。具有这些特征的患者随后被分类如下：LTNP（HIV感染≥8年且CD4细胞最低点≥500/μl），精英LTNP（HIV感染≥8年，CD4细胞最低点≥600/μl，且CD4斜率为阳性），HIV病毒控制者（HIV感染>10年，90%的血浆病毒载量值≤500拷贝/ml），以及精英控制者（与HIV病毒控制者相同，但2005年最后一次血浆病毒载量值≤50拷贝/ml）。
在2005年法国医院HIV数据库中随访的46880例HIV-1感染患者中，0.4%（N = 202）为LTNP，0.05%（N = 25）为精英LTNP，0.22%（N = 101）为HIV病毒控制者，0.15%（N = 69）为精英控制者。10例精英LTNP患者（40%）也是HIV病毒控制者，8例（32%）为精英控制者，60%的患者血浆病毒载量可检测到（>50拷贝/ml）。在精英控制者中，32例（46%）为LTNP，8例（12%）为精英LTNP，四分之一患者最后一次CD4细胞计数低于500/μl。
LTNP、精英LTNP、HIV病毒控制者和精英控制者患者是罕见的表型。精英LTNP患者比HIV病毒控制者更少见。这四类患者亚组之间几乎没有重叠。
