The London Project to Cure Blindness, Division of ORBIT, Institute of Ophthalmology, University College London, 11-43 Bath Street, London, EC1V 9EL, UK.
Development. 2013 Jun;140(12):2576-85. doi: 10.1242/dev.092270.
Stem cell therapy for retinal disease is under way, and several clinical trials are currently recruiting. These trials use human embryonic, foetal and umbilical cord tissue-derived stem cells and bone marrow-derived stem cells to treat visual disorders such as age-related macular degeneration, Stargardt's disease and retinitis pigmentosa. Over a decade of analysing the developmental cues involved in retinal generation and stem cell biology, coupled with extensive surgical research, have yielded differing cellular approaches to tackle these retinopathies. Here, we review these various stem cell-based approaches for treating retinal diseases and discuss future directions and challenges for the field.
正在进行用于治疗视网膜疾病的干细胞疗法，目前有几项临床试验正在招募患者。这些试验使用人胚胎、胎儿和脐带组织衍生的干细胞以及骨髓衍生的干细胞来治疗年龄相关性黄斑变性、斯塔加特病和色素性视网膜炎等视觉障碍。十多年来，对涉及视网膜发生和干细胞生物学的发育线索的分析，加上广泛的外科研究，产生了不同的细胞方法来治疗这些视网膜病变。在这里，我们综述了这些用于治疗视网膜疾病的基于干细胞的各种方法，并讨论了该领域的未来方向和挑战。
