Tan W C, Chan T B, Lim T K, Wong E C
Department of Medicine, National University Hospital, Singapore.
Singapore Med J. 1990 Apr;31(2):142-6.
We studied 22 Asian patients with steroid dependent asthma. Using a clinical approach to the addition of high dose inhaled budesonide and tapering of systematic steroid, we were able to substitute 5 to 20 mg prednisolone with 800 micrograms per day of inhaled budesonide in all patients. There was also a greater reduction in nocturnal symptoms and awakenings and a smaller overnight fall in PEFR during treatment with budesonide than with prednisolone. Inhaled budesonide was an effective long term substitute for prednisolone in chronic asthma.
我们研究了22名亚洲类固醇依赖型哮喘患者。通过采用临床方法增加高剂量吸入布地奈德并逐渐减少系统性类固醇用量，我们能够在所有患者中将5至20毫克泼尼松龙替换为每日800微克吸入布地奈德。与泼尼松龙治疗相比，布地奈德治疗期间夜间症状和觉醒次数减少得更多，而呼气峰流速（PEFR）的夜间下降幅度更小。吸入布地奈德是慢性哮喘中泼尼松龙的有效长期替代药物。
