Maria Fertility Clinic, 9th floor, Samsung Fire Bldg. 2-1 Beomeo 3-Dong, Suseong-Gu, Daegu, 706-743, Republic of Korea.
J Assist Reprod Genet. 2013 Jun;30(6):779-85. doi: 10.1007/s10815-013-0017-y. Epub 2013 May 30.
To compare the efficacy of single vitrified-warmed blastocyst embryo transfer (SVBT) versus double vitrified-warmed blastocyst embryo transfer (DVBT) according to the day of vitrification.
This retrospective study included a total of 1,051 cycles in women less than 37 years of age with their autologous SVBT cryopreserved on day 5 (5d-SVBT, n = 737) or day 6 (6d-SVBT, n = 154) and DVBT on day 5 (5d-DVBT, n = 129) or day 6 (6d-DVBT, n = 31) from January 2009 to December 2011.
The clinical pregnancy rate (41.8 % vs. 48.1 %, p = 0.184) and ongoing pregnancy rate (36.6 % vs. 45.0 %, p = 0.072) were not significantly different between the 5d-SVBT group and the 5d-DVBT group. However, the clinical pregnancy (29.9 % vs. 58.1 %, p = 0.003) and ongoing pregnancy rates (23.4 % vs. 51.6 %, p = 0.001) were significantly lower in the 6d-SVBT group compared with those in the 6d-DVBT group. The implantation rate (42.2 % vs. 34.5 %, p = 0.03) of the 5d-SVBT group was significantly higher than that of the 5d-DVBT group, while the implantation rate (29.9 % vs. 37.1 %, p = 0.303) of the 6d-SVBT group was not statistically different compared with that in the 6d-DVBT group. The multiple pregnancy rates (1.0 % in the 5d-SVBT group vs. 38.7 % in the 5d-DVBT group, p < 0.001 and 0 % in the 6d-SVBT group vs. 22.2 % in the 6d-DVBT group, p = 0.001) were statistically significantly lower in the SVBT group compared with those in the DVBT group regardless of the day of vitrification.
This study showed that the 5d-SVBT resulted in comparable clinical outcomes compared to the 5d-DVBT while the 6d-SVBT yielded significantly lower clinical outcomes compared to the 6d-DVBT.
根据玻璃化冷冻日比较单次玻璃化冷冻囊胚移植（SVBT）与双次玻璃化冷冻囊胚移植（DVBT）的疗效。
本回顾性研究纳入了 2009 年 1 月至 2011 年 12 月期间年龄小于 37 岁的女性共 1051 个周期，她们的自体 SVBT 分别于第 5 天（5d-SVBT，n=737）或第 6 天（6d-SVBT，n=154）进行玻璃化冷冻，或于第 5 天（5d-DVBT，n=129）或第 6 天（6d-DVBT，n=31）进行双次玻璃化冷冻。
5d-SVBT 组与 5d-DVBT 组的临床妊娠率（41.8% vs. 48.1%，p=0.184）和持续妊娠率（36.6% vs. 45.0%，p=0.072）无显著差异。然而，6d-SVBT 组的临床妊娠率（29.9% vs. 58.1%，p=0.003）和持续妊娠率（23.4% vs. 51.6%，p=0.001）明显低于 6d-DVBT 组。5d-SVBT 组的种植率（42.2% vs. 34.5%，p=0.03）明显高于 5d-DVBT 组，而 6d-SVBT 组的种植率（29.9% vs. 37.1%，p=0.303）与 6d-DVBT 组无统计学差异。无论玻璃化冷冻日如何，SVBT 组的多胎妊娠率（5d-SVBT 组 1.0% vs. 5d-DVBT 组 38.7%，p<0.001 和 6d-SVBT 组 0% vs. 6d-DVBT 组 22.2%，p=0.001）均明显低于 DVBT 组。
本研究表明，与 5d-DVBT 相比，5d-SVBT 可获得相当的临床结局，而与 6d-DVBT 相比，6d-SVBT 则可获得明显较低的临床结局。
