Hiraoka Kenichiro, Hiraoka Kaori, Miyazaki Miyuki, Fukunaga Emi, Horiuchi Toshitaka, Kusuda Tomoyo, Okano Shinichiro, Kinutani Masayuki, Kinutani Kazuo
Kinutani Women's Clinic, 8-23-4F, Hondori, Naka-ku, Hiroshima 730-0035, Japan.
J Exp Clin Assist Reprod. 2009 Oct 20;6:4.
Little information is available on perinatal outcome of cryopreserved day-7 blastocyst transfer. In the present report, perinatal outcomes for transfers of cryopreserved blastocysts by a vitrification method were examined with respect to the day of blastocyst expansion among on day 5, 6 or 7 before cryopreservation. We investigated 263 cycles of vitrified-warmed blastocyst stage embryo transfer performed between April 2005 and April 2009, which were reviewed retrospectively. There were 144 cycles with day-5 blastocyst, 100 cycles with day-6 blastocyst, and 19 cycles with day-7 blastocyst transfers. There were no differences among the vitrified day-5, day-6 and day-7 blastocyst transfer groups regarding mean number of embryos transferred, pregnancy rate, implantation rate and miscarriage rate. At this time, 71 deliveries have occurred with no reported abnormalities. There were 47 infants from 41 deliveries with day-5 blastocyst, 26 infants from 23 deliveries with day-6 blastocyst, and 8 infants from 7 deliveries with day-7 blastocyst. There were no differences among the three groups in the mean gestational age, preterm delivery rate and mean birth weight. These results indicated that blastocysts have similar inherent viability regardless of whether they develop by day 5, 6 or 7.
关于冷冻保存的第7天囊胚移植的围产期结局，目前可获得的信息较少。在本报告中，我们针对冷冻保存前第5、6或7天的囊胚扩张日，研究了采用玻璃化方法进行的冷冻保存囊胚移植的围产期结局。我们回顾性调查了2005年4月至2009年4月间进行的263个玻璃化-复温囊胚期胚胎移植周期。其中，第5天囊胚移植144个周期，第6天囊胚移植100个周期，第7天囊胚移植19个周期。在冷冻保存的第5天、第6天和第7天囊胚移植组之间，移植胚胎的平均数量、妊娠率、着床率和流产率没有差异。此时，已发生71例分娩，未报告异常情况。第5天囊胚移植的41次分娩中有47例婴儿，第6天囊胚移植的23次分娩中有26例婴儿，第7天囊胚移植的7次分娩中有8例婴儿。三组之间的平均孕周、早产率和平均出生体重没有差异。这些结果表明，无论囊胚是在第5、6或7天发育，其内在活力相似。
