Dermatologist, Bordeaux, France.
Arch Dermatol Res. 2013 Oct;305(8):673-82. doi: 10.1007/s00403-013-1360-7. Epub 2013 May 29.
Data demonstrating the efficacy of hyaluronic acid (HA)-based mesotherapy for skin rejuvenation are scarce. The aim of the study is to assess the efficacy of non-reticulated HA-based mesotherapy on skin elasticity and complexion radiance. 55 women with cutaneous ageing signs included in the Full Analysis Set (FAS) population blindly received intradermal micro-injections (50 × 0.02 mL) of non-cross-linked HA filler with mannitol (Glytone 1, HA concentration: 14 mg/g) in one cheek and saline physiological solution in the other according to hemifacial randomisation in 3 monthly sessions. Elasticity (E1 and E2 stiffness parameters) and dermis thickness were measured by cutometry and 20 MHz echography, before (D0) treatment and 1 (1M) and 3 months (3M) after the last injection. A trained panel blindly scored skin complexion radiance from standardised and calibrated photographs, using 100 mm analogue scales. In the FAS population, only HA filler significantly decreased E1 at 1M (-10.9 %, p = 0.026) and 3M (-10.5 %, p = 0.035) compared with D0; its effect versus the control tended to be more persistent, with a difference between treatments at 3M close to significance (p = 0.063). E2 also decreased at 1M (-8.2 %, p = 0.027 in the per protocol population, n = 53) and 3M after HA-treatment only. Dermis thickness significantly increased after HA-treatment at 1M (+3.4 %, p = 0.028) and 3M (+4 %, p = 0.008), and after control-treatment at 1M only (+2.5 %, p = 0.015). The HA filler significantly improved complexion radiance at 3M compared with the control (p = 0.012) and for 51 % of subjects, their skin status. Non-reticulated HA-based mesotherapy significantly and sustainably improves skin elasticity and complexion radiance.
关于透明质酸（HA）基中胚层疗法在皮肤年轻化中的功效的数据很少。本研究旨在评估非交联 HA 基中胚层疗法对皮肤弹性和肤色光泽度的疗效。55 名有皮肤老化迹象的女性纳入全分析集（FAS）人群，根据半面随机化接受真皮内微注射（50×0.02 mL）非交联 HA 填充剂与甘露醇（Glytone 1，HA 浓度：14mg/g），一侧脸颊注射，另一侧脸颊注射生理盐水生理溶液，共 3 次，每月 1 次。在治疗前（D0）和最后一次注射后 1 个月（1M）和 3 个月（3M），使用皮肤弹性计和 20MHz 超声仪分别测量弹性（E1 和 E2 硬度参数）和真皮厚度。经过标准化和校准的照片，由经过培训的小组对皮肤肤色光泽度进行盲法评分，使用 100mm 模拟量表。在 FAS 人群中，仅 HA 填充剂在 1M 时（-10.9%，p=0.026）和 3M 时（-10.5%，p=0.035）显著降低 E1，与 D0 相比；其与对照的效果似乎更持久，3M 时治疗之间的差异接近显著（p=0.063）。仅在 HA 治疗后，E2 在 1M 时（-8.2%，在符合方案人群中，n=53，p=0.027）和 3M 时也降低。真皮厚度在 HA 治疗后 1M 时（+3.4%，p=0.028）和 3M 时（+4%，p=0.008）显著增加，仅在对照治疗后 1M 时增加（+2.5%，p=0.015）。与对照相比，HA 填充剂在 3M 时显著改善肤色光泽度（p=0.012），51%的受试者皮肤状况也得到改善。非交联 HA 基中胚层疗法可显著且持续改善皮肤弹性和肤色光泽度。
