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J Cosmet Dermatol. 2012 Jun;11(2):87-92. doi: 10.1111/j.1473-2165.2012.00608.x.
Mesotherapy treatment of aging skin aims to replace depleting levels of minerals, vitamins, amino acids, and hyaluronic acid (HA).
To investigate the efficacy of 13.5 mg/g uncross-linked HA+0.9% mannitol (HA+mannitol) on skin hydration and elasticity.
PATIENTS/METHODS: Four centers enrolled 34 women: Subgroup 1 comprised 27 subjects injected using a "depot" technique; Subgroup 2 comprised seven subjects injected using a "picotage" technique.
A notable difference was seen between the two subgroups in outcome and subject satisfaction. In Subgroup 1, a significant improvement was seen in hydration, anisotropy, and skin roughness, but Subgroup 2 showed no significant improvements. Most physicians assessed HA+mannitol as "easy/very easy" to inject. Physician esthetic assessment in Subgroup 1 was "improved/very improved" for >90% of subjects at Day 60, and >80% according to subject assessment. 95% of subjects were delighted with treatment, and 85% would undergo repeat treatment and would recommend treatment to a friend. However, results for Subgroup 2 indicated 86% of subjects were unhappy with treatment and 83% would refuse to undergo repeat treatment.
HA+mannitol is effective for skin hydration, anisotropy, and roughness when treated using a depot technique.
中胚层疗法治疗衰老皮肤旨在补充矿物质、维生素、氨基酸和透明质酸（HA）的耗竭水平。
研究 13.5mg/g 未交联 HA+0.9%甘露醇（HA+甘露醇）对皮肤水合作用和弹性的疗效。
患者/方法：四家中心招募了 34 名女性：亚组 1 包括 27 名使用“储库”技术注射的受试者；亚组 2 包括 7 名使用“皮丘”技术注射的受试者。
两组在结果和受试者满意度方面存在显著差异。在亚组 1 中，水合作用、各向异性和皮肤粗糙度均有显著改善，但亚组 2 无显著改善。大多数医生评估 HA+甘露醇注射“容易/非常容易”。在第 60 天，亚组 1 中 90%以上的医生对 HA+甘露醇的美学评估为“改善/非常改善”，根据受试者评估，80%以上的医生对 HA+甘露醇的美学评估为“改善/非常改善”。95%的受试者对治疗感到满意，85%的受试者会接受重复治疗，并会向朋友推荐治疗。然而，亚组 2 的结果表明，86%的受试者对治疗不满意，83%的受试者会拒绝重复治疗。
当使用储库技术治疗时，HA+甘露醇可有效治疗皮肤水合作用、各向异性和粗糙度。
