通过无手性色谱的对映异构体自拆分进行光学纯的纯化：一系列含 α-CF3 的仲醇的案例研究。
Optical purifications via self-disproportionation of enantiomers by achiral chromatography: case study of a series of α-CF3-containing secondary alcohols.
机构信息
Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, San Sebastián, Spain.
出版信息
Chirality. 2013 Jun;25(6):365-8. doi: 10.1002/chir.22180.
PMID:23716267
Abstract
This work demonstrates that self-disproportionation of enantiomers via achiral chromatography can be recommended as inexpensive and general method for optical purification of enantiomerically enriched compounds. In particular, the advantage of this approach over conventional recrystallization is that it can be used for both crystalline as well as liquid compounds.
摘要
这项工作表明，通过非手性色谱实现对映异构体的自歧化可以作为一种经济且通用的方法，用于光学纯对映体富集化合物的纯化。特别是，与传统的重结晶相比，这种方法的优势在于它既可以用于结晶化合物，也可以用于液体化合物。
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