小纤维，大影响：小纤维神经病的生活质量。
Small fibers, large impact: quality of life in small-fiber neuropathy.
机构信息
Department of Neurology, Maastricht University Medical Centre, P.O. Box 5800, 6202 AZ, Maastricht, The Netherlands.
出版信息
Muscle Nerve. 2014 Mar;49(3):329-36. doi: 10.1002/mus.23910. Epub 2013 Jun 28.
INTRODUCTION
The impact of small-fiber neuropathy (SFN) on patients' quality of life (QOL) has not been studied extensively. Our aim was to determine the impact of SFN on QOL and examine possible determinants.
METHODS
We examined a total of 265 patients diagnosed with SFN. The SFN Symptoms Inventory Questionnaire (SFN-SIQ), the pain Visual Analog Scale (VAS), and the generic SF-36 Health Survey were assessed. Regression studies were undertaken to evaluate determinants of functioning.
RESULTS
SFN patients demonstrated a severe overall reduction in QOL. The biggest deficits were in Role Functioning-Physical, Body Pain, and Physical Component Summary (PCS) scores. VAS scores, changed sweating pattern, dry mouth, and age were the strongest predictors for PCS, explaining 32% of the QOL decrease.
CONCLUSIONS
SFN leads to a reduction in overall QOL. The presence of pain and some autonomic symptoms explained only a small portion of the findings.
简介
小纤维神经病 (SFN) 对患者生活质量 (QOL) 的影响尚未得到广泛研究。我们的目的是确定 SFN 对 QOL 的影响，并探讨可能的决定因素。
方法
我们共检查了 265 名被诊断为 SFN 的患者。评估了 SFN 症状量表问卷 (SFN-SIQ)、疼痛视觉模拟量表 (VAS) 和通用 SF-36 健康调查。进行回归研究以评估功能的决定因素。
结果
SFN 患者的整体生活质量严重下降。受影响最大的是角色功能-身体、身体疼痛和生理成分综合评分 (PCS)。VAS 评分、出汗模式改变、口干和年龄是 PCS 的最强预测因素，解释了 QOL 下降的 32%。
结论
SFN 导致整体 QOL 下降。疼痛和一些自主症状的存在仅能解释部分发现。
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