Jayanthkumar Hiriyur Shivalingappa, Murugesan Chinnamuthu, Rajkumar John, Harish Bandlapally Ramanjaneya Gupta, Muralidhar Kanchi
Department of Anaesthesiology, Narayana Hrudayalaya Institute of Medical Sciences, Bommasandra Industrial Area, Anekal Taluk, Bangalore, Karnataka, India.
Indian J Anaesth. 2013 Jan;57(1):56-61. doi: 10.4103/0019-5049.108565.
Perioperative anaesthetic management of the VentrAssist™ left ventricular assist device (LVAD) is a challenge for anaesthesiologists because patients presenting for this operation have long-standing cardiac failure and often have associated hepatic and renal impairment, which may significantly alter the pharmacokinetics of administered drugs and render the patients coagulopathic. The VentrAssist is implanted by midline sternotomy. A brief period of cardiopulmonary bypass (CPB) for apical cannulation of left ventricle is needed. The centrifugal pump, which produces non-pulsatile, continuous flow, is positioned in the left sub-diaphragmatic pocket. This LVAD is preload dependent and afterload sensitive. Transoesophageal echocardiography is an essential tool to rule out contraindications and to ensure proper inflow cannula position, and following the implantation of LVAD, to ensure right ventricular (RV) function. The anaesthesiologist should be prepared to manage cardiac decompensation and acute desaturation before initiation of CPB, as well as RV failure and severe coagulopathic bleeding after CPB. Three patients had undergone implantation of VentrAssist in our hospital. This pump provides flow of 5 l/min depending on preload, afterload and pump speed. All the patients were discharged after an average of 30 days. There was no perioperative mortality.
对于麻醉医生而言,VentrAssist™左心室辅助装置(LVAD)的围手术期麻醉管理是一项挑战,因为接受该手术的患者长期存在心力衰竭,且常伴有肝肾功能损害,这可能会显著改变所给药的药代动力学,并使患者出现凝血功能障碍。VentrAssist通过正中胸骨切开术植入。需要在短时间内进行体外循环(CPB)以进行左心室心尖插管。产生非搏动性连续血流的离心泵置于左膈下袋中。该LVAD依赖前负荷且对后负荷敏感。经食管超声心动图是排除禁忌症、确保流入插管位置正确以及在LVAD植入后确保右心室(RV)功能的重要工具。麻醉医生应准备好在CPB开始前处理心脏失代偿和急性低氧血症,以及在CPB后处理RV衰竭和严重的凝血功能障碍性出血。我院有3例患者接受了VentrAssist植入。根据前负荷、后负荷和泵速,该泵可提供5升/分钟的血流量。所有患者平均30天后出院。围手术期无死亡病例。