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huCdc7 在结直肠癌中的表达。

Expression of huCdc7 in colorectal cancer.

机构信息

Department of Oncology, Kunshan Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Kunshan 215300, Jiangsu Province, China.

出版信息

World J Gastroenterol. 2013 May 28;19(20):3130-3. doi: 10.3748/wjg.v19.i20.3130.

DOI:10.3748/wjg.v19.i20.3130
PMID:23716994
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3662954/
Abstract

AIM

To detect the expression of huCdc7 in colorectal cancer.

METHODS

The mRNA and protein expression of huCdc7 in 39 colorectal cancer tissue specimens and matched tumor-adjacent normal colorectal tissue specimens was detected by reverse transcription-polymerase chain reaction and immunohistochemistry, respectively.

RESULTS

The relative expression level of huCdc7 mRNA in colorectal cancer was significantly higher than that in tumor-adjacent normal colorectal tissues (0.03675 ± 1.00 vs 0.01199 ± 0.44, P < 0.05). huCdc7-positive cells displayed brown granules in the nucleus. Tumor tissues contained many huCdc7-positive cells, whereas normal colorectal tissues contained very few positive cells.

CONCLUSION

huCdc7 may play an important role in the development and progression of colorectal cancer.

摘要

目的

检测 huCdc7 在结直肠癌中的表达。

方法

采用逆转录-聚合酶链反应和免疫组织化学方法分别检测 39 例结直肠癌组织标本及其配对的癌旁正常结直肠组织标本中 huCdc7 的 mRNA 和蛋白表达。

结果

结直肠癌组织中 huCdc7 mRNA 的相对表达水平明显高于癌旁正常结直肠组织（0.03675 ± 1.00 比 0.01199 ± 0.44，P < 0.05）。huCdc7 阳性细胞的细胞核呈现棕色颗粒。肿瘤组织含有大量的 huCdc7 阳性细胞，而正常结直肠组织中阳性细胞很少。

结论

huCdc7 可能在结直肠癌的发生和发展中发挥重要作用。

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本文引用的文献

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Importin-beta mediates Cdc7 nuclear import by binding to the kinase insert II domain, which can be antagonized by importin-alpha.输入蛋白β通过与激酶插入结构域II结合介导Cdc7的核输入，而输入蛋白α可拮抗这种结合。
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Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells.Cdc7抑制揭示了一种p53依赖的复制检查点，该检查点在癌细胞中存在缺陷。
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