Jaafari-Ashkavandi Zohreh, Ashraf Mohammad Javad, Abbaspoorfard Ali Asghar
Shiraz University of Medical Sciences, School of Dentistry, Department of Oral and Maxillofacial Pathology, Shiraz, Iran.
Shiraz University of Medical Sciences, School of Medicine, Department of Pathology, Shiraz, Iran.
Braz J Otorhinolaryngol. 2019 Mar-Apr;85(2):144-149. doi: 10.1016/j.bjorl.2017.11.004. Epub 2017 Dec 26.
Cell division cycle-7 protein is a serine/threonine kinase that has a basic role in cell cycle regulation and is a potential prognostic or therapeutic target in some human cancers.
This study investigated the expression of cell division cycle-7 protein in benign and malignant salivary gland tumors and also its correlation with clinicopathologic factors.
Immunohistochemical expression of cell division cycle-7 was evaluated in 46 cases, including 15 adenoid cystic carcinoma, 12 mucoepidermoid carcinoma, 14 pleomorphic adenoma, and 5 normal salivary glands. Cell division cycle-7 expression rate and intensity were compared statistically.
The protein was expressed in almost all tumors. The intensity and mean of cell division cycle-7 expression were higher in malignant tumors in comparison with pleomorphic adenomas (p=0.000). The protein expression was correlated with tumor grades (p=0.000).
The present study demonstrated cell division cycle-7 overexpression in malignant salivary gland tumors in comparison with pleomorphic adenomas, and also a correlation with tumor differentiation. Therefore, this protein might be a potential prognostic and therapeutic target for salivary gland tumors.
细胞分裂周期7蛋白是一种丝氨酸/苏氨酸激酶，在细胞周期调控中起基本作用，并且是某些人类癌症中潜在的预后或治疗靶点。
本研究调查细胞分裂周期7蛋白在涎腺良恶性肿瘤中的表达情况及其与临床病理因素的相关性。
对46例病例进行细胞分裂周期7的免疫组化表达评估，包括15例腺样囊性癌、12例黏液表皮样癌、14例多形性腺瘤和5例正常涎腺。对细胞分裂周期7的表达率和强度进行统计学比较。
该蛋白在几乎所有肿瘤中均有表达。与多形性腺瘤相比，恶性肿瘤中细胞分裂周期7表达的强度和平均值更高（p=0.000）。蛋白表达与肿瘤分级相关（p=0.000）。
本研究表明，与多形性腺瘤相比，细胞分裂周期7在恶性涎腺肿瘤中过表达，并且与肿瘤分化相关。因此，该蛋白可能是涎腺肿瘤潜在的预后和治疗靶点。
