Ahn Jae-Jun, Lee Jong-Ho, Shin Min-Kyung, Lee Mu-Hyoung
Department of Dermatology, School of Medicine, Kyung Hee University, Seoul, Korea.
Ann Dermatol. 2013 May;25(2):226-8. doi: 10.5021/ad.2013.25.2.226. Epub 2013 May 10.
Vitiligo is one of the most common pigmentary skin disorders; it is characterized by circumscribed depigmented macules due to the destruction of melanocytes. Although the etiology of vitiligo has not been fully elucidated, multiple factors including autoimmune and oxidative stress have been implicated in the pathogenesis of vitiligo. In contrast, dermal melanocytosis is histologically characterized by the presence of dermal melanocytes. It has been described that there are ectopic dermal melanocytes, which have failed to reach their proper location. A literature search revealed very few reports of patients with vitiligo developing vitiligo within dermal melanocytosis. Here, we report two cases of patients with vitiligo that occurred at pre-existing sites of dermal pigmented lesions. The histopathology showed the loss of epidermal melanocytes in spite of the existence of melanocytes in the dermis. There was no significant infiltration of inflammatory cells in the dermis. These cases illustrate unknown environmental factors as well as heterogeneity.
白癜风是最常见的色素性皮肤病之一；其特征是由于黑素细胞破坏而出现局限性色素脱失斑。尽管白癜风的病因尚未完全阐明，但包括自身免疫和氧化应激在内的多种因素已被认为与白癜风的发病机制有关。相比之下，皮肤黑素细胞增多症在组织学上的特征是存在真皮黑素细胞。据描述，存在异位真皮黑素细胞，它们未能到达其正常位置。文献检索显示，关于白癜风患者在皮肤黑素细胞增多症部位发生白癜风的报道极少。在此，我们报告两例白癜风患者，其白癜风发生在先前存在的皮肤色素沉着病变部位。组织病理学显示，尽管真皮中存在黑素细胞，但表皮黑素细胞缺失。真皮中没有明显的炎症细胞浸润。这些病例说明了未知的环境因素以及异质性。
