Singh Saurabh, Elhence Poonam
Department of Dermatology All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Department of Pathology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Indian J Dermatol Venereol Leprol. 2023 Jan-Frebuary;89(1):65-70. doi: 10.25259/IJDVL_966_19.
Acquired dermal melanocytosis is a heterogenous group of hyperpigmented lesioins which predominantly involve the face.
The aim of this study was to study the clinical presentation and histopathology of cases with extra-facial acquired dermal melanocytosis.
Retrospective record analysis was performed between May 2016 to August 2019 to retrieve cases of extra-facial acquired dermal melanocytosis seen at the out-patient department of dermatology at the All India Institute of Medical Sciences, Jodhpur. Consecutive cases with histopathologically proven diagnosis of acquired dermal melanocytosis were included. Documentation of variation in clinical presentation and histopathologic findings was done in light of the existing literature.
Overall, four cases of extra-facial acquired dermal melanocyosis (female:male = 1:3) were seen during the study period. The lone case on head and neck involved the ear lobule and peri-auricular area. The other three cases had involvement of the hand. The histopathology confirmed the diagnosis of dermal melanocytosis but revealed peculiar findings of angiotropic melanocytes and dilated capillaries.
Small sample size and lack of comparison with perilesional normal skin were the limitations of this study.
The findings of angiotropic melanocytes may be unique to extra-facial acquired dermal melanocytosis. This might indicate interaction between dermal melanocytes and capillary endothelial cells. This finding along with dermal capillary ectasia may indicate a possible role for vascular lasers in the management of these disorders.
获得性皮肤黑素细胞增多症是一组色素沉着性病变的异质性疾病，主要累及面部。
本研究旨在探讨面部以外获得性皮肤黑素细胞增多症病例的临床表现和组织病理学特征。
对2016年5月至2019年8月期间在焦特布尔全印度医学科学研究所皮肤科门诊就诊的面部以外获得性皮肤黑素细胞增多症病例进行回顾性记录分析。纳入组织病理学确诊为获得性皮肤黑素细胞增多症的连续病例。根据现有文献记录临床表现和组织病理学发现的差异。
在研究期间共发现4例面部以外获得性皮肤黑素细胞增多症病例（女性：男性=1：3）。头颈部的唯一病例累及耳垂和耳周区域。另外3例累及手部。组织病理学证实为皮肤黑素细胞增多症，但发现了亲血管性黑素细胞和扩张毛细血管的特殊表现。
本研究的局限性在于样本量小以及缺乏与病变周围正常皮肤的比较。
亲血管性黑素细胞的发现可能是面部以外获得性皮肤黑素细胞增多症所特有的。这可能表明皮肤黑素细胞与毛细血管内皮细胞之间存在相互作用。这一发现连同皮肤毛细血管扩张可能提示血管激光在这些疾病治疗中可能发挥作用。
