Korea Food Research Institute, Seongnam 463-746, Korea.
J Ginseng Res. 2013 Mar;37(1):30-6. doi: 10.5142/jgr.2013.37.30.
The aim of this review was to assess the effectiveness of ginseng as a treatment option for managing menopause symptoms. We searched the literature using 11 databases from their inception to 26 September 2012 and included all randomized clinical trials (RCTs) that compared any type of ginseng to a placebo controls in postmenopausal women. The methodological quality of all studies was assessed using a Cochrane risk of bias tool. Four RCTs met our inclusion criteria. Most RCTs had high risk of bias. One RCT showed that Korean red ginseng (KRG) significantly improved sexual arousal and global health compared with placebo. Another RCT reported the superiority of KRG over placebo for treating menopause symptoms on Kupperman's index and menopausal rating score. The third RCT failed to show a significant effect of KRG on hot flash frequency compared to placebo. The fourth RCT found beneficial effects of ginseng compared to placebo on depression and well-being. In conclusion, the evidence on ginseng as an effective treatment for managing menopause symptoms is limited. Most of the RCTs are burdened with a high risk of bias. Thus firm conclusions cannot be drawn. Rigorous studies seem warranted.
本综述旨在评估人参作为治疗更年期症状的有效方法。我们使用 11 个数据库从其成立到 2012 年 9 月 26 日进行了文献检索，并纳入了所有将任何类型的人参与安慰剂对照比较的随机临床试验（RCT）。所有研究的方法学质量均使用 Cochrane 偏倚风险工具进行评估。四项 RCT 符合我们的纳入标准。大多数 RCT 具有高偏倚风险。一项 RCT 表明，与安慰剂相比，韩国红参（KRG）显著改善了性唤起和整体健康状况。另一项 RCT 报告了 KRG 在治疗更年期症状的 Kupperman 指数和更年期评分方面优于安慰剂。第三项 RCT 未能显示 KRG 对潮热频率的影响与安慰剂相比有显著差异。第四项 RCT 发现人参与安慰剂相比对抑郁和幸福感有有益的影响。总之，人参作为治疗更年期症状的有效方法的证据有限。大多数 RCT 都存在高偏倚风险。因此，无法得出明确的结论。似乎需要进行严格的研究。
