Biosafety Research Institute and College of Veterinary Medicine, Chonbuk National University, Jeonju 561-756, Korea.
J Ginseng Res. 2013 Apr;37(2):210-8. doi: 10.5142/jgr.2013.37.210.
Numerous studies have suggested that Korean red ginseng (KRG) extract has various immune modulatory activities both in vivo and in vitro. In this study, we used a mouse model to examine the effects of orally administered KRG extract on immunity against herpes simplex virus (HSV). Balb/c mice were administered with 100, 200, and 400 mg/kg oral doses of KRG extract for 10 d and then vaginally infected with HSV. We found that KRG extract rendered recipients more resistant against HSV vaginal infection and further systemic infection, including decreased clinical severity, increased survival rate, and accelerated viral clearance. Such results appeared to be mediated by increased vaginal IFN-γ secretion. Moreover, increased mRNA expression of IFN-γ, granzyme B, and Fas-ligand was identified in the iliac lymph node and vaginal tracts of KRG extract treated groups (200 and 400 mg/kg). These results suggest that the activities of local natural killer cells were promoted by KRG extract consumption and that KRG may be an attractive immune stimulator for helping hosts overcome HSV infection.
许多研究表明，红参提取物（KRG）在体内和体外均具有多种免疫调节作用。在这项研究中，我们使用小鼠模型来研究口服 KRG 提取物对单纯疱疹病毒（HSV）免疫的影响。Balb/c 小鼠口服给予 100、200 和 400 mg/kg 的 KRG 提取物 10 天，然后阴道感染 HSV。我们发现，KRG 提取物使受者对 HSV 阴道感染和进一步的全身感染更具抵抗力，包括临床严重程度降低、生存率提高和病毒清除加快。这些结果似乎是通过增加阴道 IFN-γ 分泌介导的。此外，在 KRG 提取物处理组（200 和 400 mg/kg）的髂淋巴结和阴道组织中，鉴定出 IFN-γ、颗粒酶 B 和 Fas 配体的 mRNA 表达增加。这些结果表明，KRG 提取物的消耗促进了局部自然杀伤细胞的活性，并且 KRG 可能是一种有吸引力的免疫刺激剂，有助于宿主克服 HSV 感染。
