College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Korea.
J Ginseng Res. 2011 Sep;35(3):294-300. doi: 10.5142/jgr.2011.35.3.294.
Zearalenone (ZEA) is a phenolic resorcylic acid lactone compound produced by several species of Fusarium. ZEA has toxic effects in the testes of domestic and laboratory animals. Korean red ginseng (KRG), the steamed root of Panax ginseng Meyer, has multiple pharmacological effects such as vasorelaxation, anti-thrombosis, anti-hypertension, etc. In this study, we investigated the effects of KRG extract on testicular toxicity induced by ZEA. Rats were treated with 300 mg/kg oral doses of KRG for 4 weeks every other day. The rats were then treated with a single dose of 5 mg/kg ZEA delivered intraperitoneally, whereas control rats received only doses of the vehicle. As a result, germ cell apoptosis induced by ZEA was decreased by KRG pre-treatment. In addition, Fas and Fas-L expression was reduced in rats that received KRG pre-treatment compared to ones treated with ZEA alone. In conclusion, impaired spermatogenesis resulting from ZEA treatment was prevented by KRG through Fas-Fas L modulating.
玉米赤霉烯酮（ZEA）是由几种镰刀菌产生的酚类雷琐酸内酯化合物。ZEA 对家兔和实验动物的睾丸具有毒性作用。韩国红参（KRG）是 Panax ginseng Meyer 的蒸根，具有血管舒张、抗血栓形成、抗高血压等多种药理作用。在这项研究中，我们研究了 KRG 提取物对 ZEA 诱导的睾丸毒性的影响。大鼠每隔一天口服 300mg/kg 的 KRG 提取物，共 4 周。然后，大鼠腹腔内给予单次 5mg/kg 的 ZEA 剂量，而对照组大鼠仅给予载体剂量。结果表明，KRG 预处理可减少 ZEA 诱导的精母细胞凋亡。此外，与单独用 ZEA 处理的大鼠相比，用 KRG 预处理的大鼠 Fas 和 Fas-L 的表达减少。总之，通过 Fas-FasL 调节，KRG 预防了 ZEA 处理引起的精子发生受损。
