Department of Radiology, Boston University School of Medicine, Boston, MA 02118, USA.
Rheum Dis Clin North Am. 2013 Aug;39(3):567-91. doi: 10.1016/j.rdc.2013.02.001. Epub 2013 Feb 23.
Slowing of radiographic joint space narrowing represents the only recommended imaging-based outcome measure to assess structural disease progression in osteoarthritis (OA) clinical trials. There are no effective disease-modifying OA drugs. The ability of magnetic resonance (MR) to image structures within the knee and to visualize cartilage morphology and composition gives MR imaging a critical role in understanding the natural history of the disease and in the search for therapies. In this article, the roles and limitations of conventional radiography and MR imaging, focusing on knee OA, and the use of other modalities in clinical practice and OA research are described.
影像学关节间隙狭窄进展的减缓是评估骨关节炎（OA）临床试验中结构性疾病进展的唯一推荐的基于影像学的疗效评估手段。目前尚无有效的治疗 OA 的药物。磁共振（MR）成像技术可用于膝关节内结构成像，还可用于显示软骨形态和成分，这使其在了解疾病自然史和探寻治疗方法方面发挥了重要作用。本文描述了常规放射摄影术和磁共振成像（重点为膝关节 OA）的作用和局限性，以及在临床实践和 OA 研究中其他方式的应用。
