Department of Radiology, Quantitative Imaging Center (QIC), Boston University School of Medicine, 820 Harrison Avenue, FGH Building, 3rd Floor, Boston, MA 02118, USA; Department of Radiology, University of Erlangen-Nuremberg, Maximiliansplatz 1, 91054 Erlangen, Germany; Department of Radiology, Klinikum Augsburg, Augsburg, Stenglinstr 2, 86156 Augsburg, Germany.
Institute of Anatomy, Paracelsus Medical University, Strubergasse 21, 5020 Salzburg, Austria.
Best Pract Res Clin Rheumatol. 2014 Feb;28(1):31-60. doi: 10.1016/j.berh.2014.02.002.
Osteoarthritis (OA) is the most prevalent joint disorder with no approved disease-modifying treatment available. The importance of imaging in assessing all joint structures involved in the disease process, including articular cartilage, meniscus, subarticular bone marrow, and synovium for diagnosis, prognostication, and follow-up, has been well recognized. In daily clinical practice, conventional radiography is still the most commonly used imaging technique for the evaluation of a patient with known or suspected OA and radiographic outcome measures are still the only approved end point by regulatory authorities in clinical trials. The ability of magnetic resonance imaging (MRI) to visualize all joint structures in three-dimensional fashion including tissue ultrastructure has markedly deepened our understanding of the natural history of the disease. This article describes the roles and limitations of different imaging modalities for clinical practice and research in OA, with a focus on radiography and MRI and an emphasis on the knee joint.
骨关节炎（OA）是最常见的关节疾病，目前尚无可用的疾病修正治疗方法。影像学在评估包括关节软骨、半月板、软骨下骨骨髓和滑膜在内的所有参与疾病过程的关节结构中的作用已得到充分认识，这对诊断、预后和随访都非常重要。在日常临床实践中，传统放射摄影仍然是评估已知或疑似 OA 患者最常用的影像学技术，放射学结果测量仍然是监管机构在临床试验中唯一批准的终点。磁共振成像（MRI）能够以三维方式可视化所有关节结构，包括组织超微结构，这极大地加深了我们对疾病自然史的理解。本文描述了不同影像学方法在 OA 临床实践和研究中的作用和局限性，重点介绍放射摄影和 MRI，并强调膝关节。
