2nd Department of Surgery, Areteion Hospital, School of Medicine, University of Athens, Athens, Greece.
Pancreatology. 2013 May-Jun;13(3):273-8. doi: 10.1016/j.pan.2013.02.005. Epub 2013 Feb 28.
MicroRNAs (miRNAs) act as regulators of gene expression via translational repression. Single nucleotide polymorphisms (SNPs) in miRNAs have been shown to affect the regulatory capacity of miRNAs by influencing miRNA processing and/or miRNA-mRNA interactions. The purpose of this study was to investigate the association between 2 SNPs commonly found in precursor miRNA and the susceptibility and clinicopathological characteristics of pancreatic cancer. The rs11614913/miR-196a2, rs2910164/miR-146a SNPs were genotyped in 93 patients with pancreatic cancer and in 122 healthy controls. No significant differences in genotype distributions between controls and PC patients were observed. However, rs2910164 GG and rs11614913 CC genotypes and the rs2910164C/rs11614913C and rs2910164G/rs11614913C haplotypes were significantly overrepresented in PC patients with T1 and T2 tumor status than in those with T3 and T4. Our findings suggested that the rs2910164 and rs11614913 SNPs might play a role in pancreatic tumorigenesis, but the molecular mechanism underlying the particular sequence variations in miRNA that can cause aberrant expression remains to be determined.
微小 RNA（miRNA）通过翻译抑制作用作为基因表达的调节剂。已经表明，miRNA 中的单核苷酸多态性（SNP）通过影响 miRNA 加工和/或 miRNA-mRNA 相互作用来影响 miRNA 的调节能力。本研究旨在探讨常见前体 miRNA 中的 2 个 SNP 与胰腺癌易感性和临床病理特征之间的关联。在 93 例胰腺癌患者和 122 例健康对照中对 rs11614913/miR-196a2、rs2910164/miR-146a SNP 进行了基因分型。在对照组和 PC 患者之间未观察到基因型分布的显着差异。然而，rs2910164 GG 和 rs11614913 CC 基因型以及 rs2910164C/rs11614913C 和 rs2910164G/rs11614913C 单倍型在 T1 和 T2 肿瘤状态的 PC 患者中明显高于 T3 和 T4。我们的研究结果表明，rs2910164 和 rs11614913 SNP 可能在胰腺癌发生中起作用，但导致异常表达的 miRNA 中特定序列变异的分子机制仍有待确定。
