Dikaiakos Panagiotis, Gazouli Maria, Rizos Spyros, Zografos George, Theodoropoulos George E
First Surgical Department, Tzaneion Hospital, Piraeus, Greece.
Department of Basic Medical Science, Laboratory of Biology, School of Medicine, University of Athens, Athens, Greece.
Cancer Biomark. 2015;15(2):157-62. doi: 10.3233/CBM-140449.
Aberrant expression and structural alteration of miRNAs are considered to participate in cancer development. It has been suggested that common single-nucleotide polymorphisms (SNPs) in miRNAs are associated with susceptibility to several human diseases including colorectal cancer (CRC).
A case-control study at 157 CRC patients and 299 healthy controls of Greek origin was undertaken in order to investigate the association between the genotype and allelic frequencies of three common SNPs (rs2910164, rs11614913 and rs3746444) in pre-miRNAs, miR-146a, miR-196a2 and miR-499.
The risk for CRC was significantly higher at the carriers of miR-146a rs2910164 CC genotype and C allele (p=0.02 and p< 0.001, respectively). None of the other performed analysis showed any statistically significant results.
Our findings suggest that the rs2910164 polymorphism in pre-miRNA, miR-146a may be associated with the risk of CRC.
微小RNA（miRNA）的异常表达和结构改变被认为参与癌症发展。有人提出，miRNA中的常见单核苷酸多态性（SNP）与包括结直肠癌（CRC）在内的几种人类疾病的易感性相关。
对157例希腊裔结直肠癌患者和299例健康对照进行病例对照研究，以调查前体miRNA miR-146a、miR-196a2和miR-499中三个常见SNP（rs2910164、rs11614913和rs3746444）的基因型和等位基因频率之间的关联。
miR-146a rs2910164 CC基因型和C等位基因携带者患结直肠癌的风险显著更高（分别为p = 0.02和p < 0.001）。其他分析均未显示任何具有统计学意义的结果。
我们的研究结果表明，前体miRNA miR-146a中的rs2910164多态性可能与结直肠癌风险相关。
