• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

猫视黄醇结合蛋白4的分子特征及组织分布

Molecular characterization and tissue distribution of feline retinol-binding protein 4.

作者信息

Sasaki Noriyasu, Ishibashi Miwa, Soeta Satoshi

机构信息

Laboratory of Veterinary Biochemistry, School of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo 180-8602, Japan.

出版信息

J Vet Med Sci. 2013 Oct;75(10):1383-7. doi: 10.1292/jvms.13-0131. Epub 2013 May 28.

DOI:10.1292/jvms.13-0131
PMID:23719693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3942945/
Abstract

Retinol-binding protein 4 (RBP4) is a specific transporter of retinol and was recently identified as an adipokine potentially involved in type 2 diabetes in humans and rodents. However, the function and structure of feline RBP4 have not been reported. In this study, we describe the molecular cloning and expression analysis of feline RBP4. The complete feline RBP4 cDNA encodes a precursor protein comprising an 18 amino acid signal peptide and a 183 amino acid mature protein. Feline RBP4 was mapped to chromosome D2. Mature feline RBP4 is 83-94% homologous to the RBPs of humans, cows and rodents. RT-PCR analysis revealed feline RBP4 expression in liver and adipose tissues.

摘要

视黄醇结合蛋白4（RBP4）是视黄醇的一种特异性转运蛋白，最近被确定为一种脂肪因子，可能与人类和啮齿动物的2型糖尿病有关。然而，猫RBP4的功能和结构尚未见报道。在本研究中，我们描述了猫RBP4的分子克隆和表达分析。猫RBP4的完整cDNA编码一种前体蛋白，该前体蛋白包含一个18个氨基酸的信号肽和一个183个氨基酸的成熟蛋白。猫RBP4被定位到D2染色体上。成熟的猫RBP4与人类、牛和啮齿动物的RBP具有83%-94%的同源性。RT-PCR分析显示猫RBP4在肝脏和脂肪组织中表达。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a3a/3942945/a88489e32f19/jvms-75-1383-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a3a/3942945/aaa5969f3030/jvms-75-1383-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a3a/3942945/f872b3006e96/jvms-75-1383-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a3a/3942945/a88489e32f19/jvms-75-1383-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a3a/3942945/aaa5969f3030/jvms-75-1383-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a3a/3942945/f872b3006e96/jvms-75-1383-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a3a/3942945/a88489e32f19/jvms-75-1383-g003.jpg

相似文献

1
Molecular characterization and tissue distribution of feline retinol-binding protein 4.猫视黄醇结合蛋白4的分子特征及组织分布
J Vet Med Sci. 2013 Oct;75(10):1383-7. doi: 10.1292/jvms.13-0131. Epub 2013 May 28.
2
CDNA cloning of feline leptin and its mRNA expression in adipose tissue.
J Vet Med Sci. 2001 Oct;63(10):1115-20. doi: 10.1292/jvms.63.1115.
3
Cloning and sequencing of feline thyrotropin (fTSH): heterodimeric and yoked constructs.猫促甲状腺激素（fTSH）的克隆与测序：异源二聚体和轭合构建体
Domest Anim Endocrinol. 2006 Mar;30(3):203-17. doi: 10.1016/j.domaniend.2005.07.002. Epub 2005 Aug 9.
4
Molecular cloning and phylogenetic analysis of a cDNA encoding the cat (Felis domesticus) Ig epsilon constant region.编码猫（家猫）Ig epsilon恒定区的cDNA的分子克隆及系统发育分析。
Vet Immunol Immunopathol. 2000 Oct 31;76(3-4):299-308. doi: 10.1016/s0165-2427(00)00215-4.
5
Molecular cloning of a cDNA coding for feline liver xanthine dehydrogenase.猫肝脏黄嘌呤脱氢酶编码cDNA的分子克隆
J Vet Med Sci. 2001 Mar;63(3):353-5. doi: 10.1292/jvms.63.353.
6
Cloning, expression and purification of feline proinsulin.猫胰岛素原的克隆、表达及纯化
Domest Anim Endocrinol. 2006 Jan;30(1):28-37. doi: 10.1016/j.domaniend.2005.05.005. Epub 2005 Jun 15.
7
Liver retinol transporter and receptor for serum retinol-binding protein (RBP4).肝脏视黄醇转运蛋白和血清视黄醇结合蛋白（RBP4）受体。
J Biol Chem. 2013 Jan 11;288(2):1250-65. doi: 10.1074/jbc.M112.369132. Epub 2012 Oct 26.
8
Sequence analysis and expression regulation of rbp4 by 9-cis-RA in Megalobrama amblycephala.9-顺式视黄酸对团头鲂rbp4的序列分析及表达调控
Fish Physiol Biochem. 2015 Apr;41(2):437-47. doi: 10.1007/s10695-014-9995-7. Epub 2014 Oct 2.
9
Molecular cloning and expression analysis of feline melanoma antigen (MAGE) obtained from a lymphoma cell line.
Vet Immunol Immunopathol. 2001 Dec;83(3-4):241-52. doi: 10.1016/s0165-2427(01)00384-1.
10
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes.血清视黄醇结合蛋白4在肥胖症和2型糖尿病中导致胰岛素抵抗。
Nature. 2005 Jul 21;436(7049):356-62. doi: 10.1038/nature03711.

引用本文的文献

1
Pet Wellness and Vitamin A: A Narrative Overview.宠物健康与维生素A：概述
Animals (Basel). 2024 Mar 25;14(7):1000. doi: 10.3390/ani14071000.

本文引用的文献

1
Quantitative measurement of full-length and C-terminal proteolyzed RBP4 in serum of normal and insulin-resistant humans using a novel mass spectrometry immunoassay.采用新型质谱免疫分析法定量检测正常人和胰岛素抵抗患者血清中全长和 C 端蛋白水解 RBP4。
Endocrinology. 2012 Mar;153(3):1519-27. doi: 10.1210/en.2011-1750. Epub 2012 Jan 17.
2
Retinol-binding protein 4 is not associated with insulin resistance in pregnancy.视黄醇结合蛋白 4与妊娠胰岛素抵抗无关。
Metabolism. 2012 Jan;61(1):65-9. doi: 10.1016/j.metabol.2011.05.019. Epub 2011 Jul 7.
3
Retinol-binding protein in serum and urine of hyperthyroid cats before and after treatment with radioiodine.
放射性碘治疗前后甲亢猫血清和尿液中的视黄醇结合蛋白
J Vet Intern Med. 2009 Sep-Oct;23(5):1031-7. doi: 10.1111/j.1939-1676.2009.0364.x. Epub 2009 Aug 11.
4
Evidence that kidney function but not type 2 diabetes determines retinol-binding protein 4 serum levels.肾功能而非2型糖尿病决定视黄醇结合蛋白4血清水平的证据。
Diabetes. 2008 Dec;57(12):3323-6. doi: 10.2337/db08-0866. Epub 2008 Sep 16.
5
Plasma retinol-binding protein is not a marker of insulin resistance in overweight subjects: a three year longitudinal study.血浆视黄醇结合蛋白不是超重受试者胰岛素抵抗的标志物：一项为期三年的纵向研究。
Clin Biochem. 2008 Sep;41(13):1034-8. doi: 10.1016/j.clinbiochem.2008.06.002. Epub 2008 Jun 13.
6
Immunoassay of urinary retinol binding protein as a putative renal marker in cats.猫尿视黄醇结合蛋白作为一种假定的肾脏标志物的免疫测定
J Immunol Methods. 2008 Jan 1;329(1-2):208-13. doi: 10.1016/j.jim.2007.10.006. Epub 2007 Oct 31.
7
Insulin resistance is unrelated to circulating retinol binding protein and protein C inhibitor.胰岛素抵抗与循环视黄醇结合蛋白及蛋白C抑制剂无关。
J Clin Endocrinol Metab. 2007 Nov;92(11):4306-12. doi: 10.1210/jc.2006-2522. Epub 2007 Aug 28.
8
Feline diabetes mellitus in the UK: the prevalence within an insured cat population and a questionnaire-based putative risk factor analysis.英国猫糖尿病：投保猫群体中的患病率及基于问卷调查的假定风险因素分析
J Feline Med Surg. 2007 Aug;9(4):289-99. doi: 10.1016/j.jfms.2007.02.001. Epub 2007 Mar 27.
9
High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans.循环视黄醇结合蛋白4水平升高与人类肝脏脂肪增加有关，但与总体脂肪、皮下脂肪、内脏脂肪或肌内脂肪无关。
Diabetes Care. 2007 May;30(5):1173-8. doi: 10.2337/dc06-2342. Epub 2007 Jan 26.
10
Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes.在糖耐量受损和2型糖尿病患者中，血浆视黄醇结合蛋白4浓度升高。
Diabetes Care. 2006 Nov;29(11):2457-61. doi: 10.2337/dc06-0360.