Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Biomaterials. 2010 Feb;31(6):1017-24. doi: 10.1016/j.biomaterials.2009.10.055. Epub 2009 Nov 10.
Poly(ether-ether-ketone) (PEEK)s are a group of polymeric biomaterials with excellent mechanical properties and chemical stability. In the present study, we demonstrate the fabrication of an antibiofouling and highly hydrophilic high-density nanometer-scaled layer on the surface of PEEK by photo-induced graft polymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) without using any photo-initiators, i.e., "self-initiated surface graft polymerization." Our results indicated that the diphenylketone moiety in the polymer backbone acted as a photo-initiator similar to benzophenone. The density and thickness of the poly(MPC) (PMPC)-grafted layer were controlled by the photo-irradiation time and monomer concentration during polymerization, respectively. Since MPC is a highly hydrophilic compound, the water wettability (contact angle <10 degrees) and lubricity (coefficient of dynamic friction <0.01) of the PMPC-grafted PEEK surface were considerably lower than those of the untreated PEEK surface (90 degrees and 0.20, respectively) due to the formation of a PMPC nanometer-scale layer. In addition, the amount (0.05 microg/cm(2)) of BSA adsorbed on the PMPC-grafted PEEK surface was considerably lower, that is more than 90% reduction, compared to that (0.55 microg/cm(2)) for untreated PEEK. This photo-induced polymerization process occurs only on the surface of the PEEK substrate; therefore, the desirable mechanical properties of PEEK would be maintained irrespective of the treatment used.
聚醚醚酮（PEEK）是一组具有优异机械性能和化学稳定性的聚合生物材料。在本研究中，我们展示了通过光诱导接枝聚合 2-甲基丙烯酰氧基乙基磷酰胆碱（MPC）在 PEEK 表面上制造抗生物污损和高度亲水性的高密度纳米级层，而无需使用任何光引发剂，即“自引发表面接枝聚合”。我们的结果表明，聚合物主链中的二苯甲酮部分充当类似于苯甲酮的光引发剂。聚（MPC）（PMPC）接枝层的密度和厚度分别通过聚合过程中的光照射时间和单体浓度来控制。由于 MPC 是一种高度亲水的化合物，因此 PMPC 接枝 PEEK 表面的润湿性（接触角<10 度）和润滑性（动摩擦系数<0.01）明显低于未经处理的 PEEK 表面（分别为 90 度和 0.20），这是由于形成了 PMPC 纳米级层。此外，与未经处理的 PEEK（0.55μg/cm2）相比，PMPC 接枝 PEEK 表面上吸附的 BSA 量（0.05μg/cm2）明显较低，即减少了 90%以上。这种光诱导聚合过程仅发生在 PEEK 基底的表面上；因此，无论使用何种处理方法，都可以保持 PEEK 的理想机械性能。
