利用异硫氰酸酯的多组分反应进行功能化噻唑的无溶剂合成。
Solvent-free synthesis of functionalized thiazoles using multicomponent reaction of isothiocyanates.
作者信息
Sayyed-Alangi Seyyedeh Zahra, Hossaini Zinatossadat, Rostami-Charati Faramarz, Sajjadi-Ghotabadi Hadi
机构信息
Department of Chemistry, Azadshahr Branch, Islamic Azad University, Azadshahr, Iran.
出版信息
Comb Chem High Throughput Screen. 2013 Nov;16(9):758-61. doi: 10.2174/13862073113169990036.
PMID:23721069
Abstract
An efficient synthesis of thiazoles is described via an one-pot reaction between acid chlorides, ammonium thiocyanate tetramethylguanidine and α-bromocarbonyl compounds under solvent-free conditions without using any catalyst. The method offers several advantages including high yields of products and an easy work-up procedure at room temperature in excellent yield.
摘要
描述了一种在无溶剂条件下，通过酰氯、硫氰酸铵、四甲基胍与α-溴代羰基化合物之间的一锅反应高效合成噻唑的方法，该方法无需使用任何催化剂。该方法具有多个优点，包括产物收率高，且在室温下后处理程序简便，收率优异。
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