Schüttler J
Institut für Anästhesiologie der Rheinischen Friedrich-Wilhelms-Universität Bonn, Venusberg.
Ann Fr Anesth Reanim. 1990;9(3):208-11. doi: 10.1016/s0750-7658(05)80172-8.
Deep endobronchial instillation of epinephrine (2-5 mg in 5 ml saline, catheter of 50 cm in length), during cardiopulmonary resuscitation in man, results rapidly in efficient blood concentrations, similar to those obtained with i.v. route, but with the additional benefit of a more prolonged effect, due to a slower blood concentration decrease. Despite the large interindividual variations in resulting blood concentrations, also observed with the i.v. route, the endobronchial instillation of lidocaine (5-7 mg.kg-1 in 10 ml saline) results in most cases in blood concentrations located in the therapeutic range. As with epinephrine, the endobronchial route results in a prolonged, infusion-like effect. This can be of benefit for the prevention of recurrent ventricular fibrillation. This study provides further arguments for a more extensive use of the endobronchial route, especially in out-of-hospital resuscitation.
在对人类进行心肺复苏期间，经深度支气管内滴注肾上腺素（5毫升生理盐水中含2 - 5毫克，使用50厘米长的导管），能迅速达到有效的血药浓度，与静脉注射途径所获浓度相似，但由于血药浓度下降较慢，其效果持续时间更长。尽管静脉注射途径也存在个体间血药浓度的巨大差异，但经支气管内滴注利多卡因（10毫升生理盐水中含5 - 7毫克/千克）在大多数情况下能使血药浓度处于治疗范围内。与肾上腺素一样，支气管内给药途径会产生持续时间长、类似输注的效果。这对于预防心室颤动复发可能有益。本研究为更广泛地使用支气管内给药途径提供了进一步依据，尤其是在院外复苏中。
