Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
Respir Physiol Neurobiol. 2013 Sep 15;188(3):355-61. doi: 10.1016/j.resp.2013.05.022. Epub 2013 May 27.
Rodent models of sleep apnea have long been used to provide novel insight into the generation and predisposition to apneas as well as to characterize the impact of sleep apnea on cardiovascular, metabolic, and psychological health in humans. Given the significant body of work utilizing rodent models in the field of sleep apnea, the aims of this review are three-fold: first, to review the use of rodents as natural models of sleep apnea; second, to provide an overview of the experimental interventions employed in rodents to simulate sleep apnea; third, to discuss the refinement of rodent models to further our understanding of breathing abnormalities that occur during sleep. Given mounting evidence that sleep apnea impairs cognitive function, reduces quality of life, and exacerbates the course of multiple chronic diseases, rodent models will remain a high priority as a tool to interrogate both the pathophysiology and sequelae of breathing related abnormalities during sleep and to improve approaches to diagnosis and therapy.
啮齿动物睡眠呼吸暂停模型长期以来一直被用于提供对呼吸暂停的产生和易感性的新见解，以及描述睡眠呼吸暂停对人类心血管、代谢和心理健康的影响。鉴于在睡眠呼吸暂停领域利用啮齿动物模型进行了大量的工作，本综述的目的有三：第一，回顾啮齿动物作为睡眠呼吸暂停自然模型的应用；第二，提供在啮齿动物中模拟睡眠呼吸暂停所采用的实验干预措施的概述；第三，讨论啮齿动物模型的改进，以进一步了解睡眠期间发生的呼吸异常。鉴于越来越多的证据表明睡眠呼吸暂停会损害认知功能、降低生活质量，并加重多种慢性疾病的进程，啮齿动物模型仍将作为一种工具处于高度优先地位，用于探究睡眠期间与呼吸相关的异常的病理生理学及其后果，并改善诊断和治疗方法。
