用于视网膜血氧测量的可见光学相干断层扫描。
Visible-light optical coherence tomography for retinal oximetry.
机构信息
Department of Biomedical Engineering, Northwestern University, Evanston, Illinois 60208, USA.
出版信息
Opt Lett. 2013 Jun 1;38(11):1796-8. doi: 10.1364/OL.38.001796.
Abstract
We applied a visible-light spectroscopic optical coherence tomography (vis-OCT) for in vivo retinal oximetry. To extract hemoglobin oxygen saturation (sO(2)) in individual retinal vessels, we established a comprehensive analytical model to describe optical absorption, optical scattering, and blood cell packing factor in the whole blood and fit the acquired vis-OCT signals from the bottom of each imaged vessel. We found that averaged sO(2) values in arterial and venous bloods were 95% and 72%, respectively.
摘要
我们应用可见光谱光学相干断层扫描（vis-OCT）进行活体视网膜血氧测定。为了从每个成像血管的底部提取单个视网膜血管中的血红蛋白氧饱和度（sO(2)），我们建立了一个综合分析模型来描述全血中的光吸收、光散射和血细胞堆积因子，并拟合所获得的 vis-OCT 信号。我们发现动脉血和静脉血的平均 sO(2)值分别为 95%和 72%。
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本文引用的文献
1
Molecular imaging true-colour spectroscopic optical coherence tomography.分子成像真彩色光谱光学相干断层扫描
Nat Photonics. 2011 Dec 1;5(12):744-747. doi: 10.1038/nphoton.2011.257. Epub 2011 Oct 23.
2
Imaging a full set of optical scattering properties of biological tissue by inverse spectroscopic optical coherence tomography.利用逆光谱光学相干层析成像技术对生物组织的全套光学散射特性进行成像。
Opt Lett. 2012 Nov 1;37(21):4443-5. doi: 10.1364/OL.37.004443.
3
Assessing hemoglobin concentration using spectroscopic optical coherence tomography for feasibility of tissue diagnostics.使用光谱光学相干断层扫描评估血红蛋白浓度以确定组织诊断的可行性。
Biomed Opt Express. 2010 Jul 27;1(1):310-317. doi: 10.1364/boe.1.000310/.
4
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5
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Opt Lett. 2008 Mar 1;33(5):416-8. doi: 10.1364/ol.33.000416.
6
Optical scattering properties of soft tissue: a discrete particle model.软组织的光学散射特性：离散粒子模型
Appl Opt. 1998 May 1;37(13):2788-97. doi: 10.1364/ao.37.002788.
7
Spectral measurement of absorption by spectroscopic frequency-domain optical coherence tomography.通过光谱频域光学相干断层扫描进行吸收的光谱测量。
Opt Lett. 2000 Jun 1;25(11):820-2. doi: 10.1364/ol.25.000820.
8
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9
Unified Mie and fractal scattering by biological cells and subcellular structures.生物细胞和亚细胞结构的统一米氏散射和分形散射
Opt Lett. 2007 Aug 15;32(16):2324-6. doi: 10.1364/ol.32.002324.
10
Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging.用于高分辨率和无创体内成像的功能光声显微镜
Nat Biotechnol. 2006 Jul;24(7):848-51. doi: 10.1038/nbt1220. Epub 2006 Jun 25.
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