History of Medicine Department, Medical School, University of Athens, , Athens, Greece.
Thorax. 2013 Oct;68(10):978-9. doi: 10.1136/thoraxjnl-2013-203840. Epub 2013 May 30.
For more than 1500 years, the status of knowledge concerning the physiology of human respiration has remained almost unchanged. In the 18th century, the French chemist Antoine-Laurent de Lavoisier conducted breathing experiments on human and animal respiration.
The main bibliographic sources concerning Lavoisier's life and work on respiration have been investigated and analysed.
Using an ice-calorimeter, Lavoisier proved that combustion and respiration were one and the same. He also measured the oxygen consumed during respiration and concluded that the amount changes depending on human activities: exercise, eating, fasting, and sitting in a warm or cold room. Moreover, he found variations in pulse and breathing rate.
Lavoisier's work on respiration is of great historical significance as it represents the first effort to measure human respiratory gas metabolism contributing significantly to the development of respiratory physiology.
1500 多年来，人类呼吸生理学知识的地位几乎没有变化。18 世纪，法国化学家 Antoine-Laurent de Lavoisier 对人和动物的呼吸进行了呼吸实验。
调查和分析了有关 Lavoisier 生命和呼吸工作的主要文献来源。
Lavoisier 使用冰量热计证明了燃烧和呼吸是一回事。他还测量了呼吸过程中消耗的氧气，并得出结论，氧气的消耗量取决于人的活动：运动、进食、禁食和坐在温暖或寒冷的房间里。此外，他还发现了脉搏和呼吸频率的变化。
Lavoisier 的呼吸工作具有重要的历史意义，因为它代表了首次尝试测量人体呼吸气体代谢的努力，这对呼吸生理学的发展做出了重大贡献。
