Bist Sampan S, Bisht Manisha, Purohit Jagdish P, Saxena Ratna
Department of ENT & Pharmacology, Himalayan Institute of Medical Sciences, Dehradun 248140, India.
ISRN Otolaryngol. 2011 Dec 26;2011:269479. doi: 10.5402/2011/269479. Print 2011.
Primary atrophic rhinitis is a progressive chronic nasal disease and histopathologically characterized by squamous metaplasia and two characteristic types of vascular involvement (type I and type II). Despite its chronicity and squamous transformation, nothing is known about the occurrence of malignancy in atrophic rhinitis. The present work was undertaken to study the histopathological characteristics in primary atrophic rhinitis and identify whether it has any association with malignant transformation. Nasal biopsies obtained from 90 patients diagnosed as primary atrophic rhinitis were studied. Squamous metaplasia was noted in 89% of patients, and type I and type II vascular involvement were seen in 67% and 33% of patients, respectively. This preliminary report suggests that there is no association between atrophic rhinitis and precancerous lesions of nasal cavity despite squamous metaplasia and confirms the presence of two types of vascular changes in the disease which is helpful to decide the treatment modality.
原发性萎缩性鼻炎是一种进行性慢性鼻腔疾病，其组织病理学特征为鳞状化生和两种特征性血管病变类型（I型和II型）。尽管其具有慢性病程和鳞状化生，但关于萎缩性鼻炎中恶性肿瘤的发生情况尚无定论。本研究旨在探讨原发性萎缩性鼻炎的组织病理学特征，并确定其是否与恶性转化有关。对90例诊断为原发性萎缩性鼻炎的患者的鼻腔活检组织进行了研究。89%的患者出现鳞状化生，I型和II型血管病变分别见于67%和33%的患者。本初步报告表明，尽管存在鳞状化生，但萎缩性鼻炎与鼻腔癌前病变之间并无关联，并证实了该疾病中存在两种血管变化类型，这有助于确定治疗方式。
