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尼日尔尼亚美未接受治疗患者中HIV-1的基因多样性和耐药性突变

Genetic Diversity and Drug Resistance Mutations in HIV-1 from Untreated Patients in Niamey, Niger.

作者信息

Mamadou Saïdou, Hanki Yahayé, Ali Maazou Amadou Roufaï, Aoula Balki, Diallo Sanata

机构信息

Laboratory of Bacteriology-Virology, Faculty of Health Sciences, Abdou Moumouni University, P.O. Box 237, Niamey, Niger ; National Reference Laboratory for STI/HIV/TB, P.O. Box 10 146, Niamey, Niger.

出版信息

ISRN Microbiol. 2011 Nov 3;2011:797463. doi: 10.5402/2011/797463. Print 2011.

DOI:10.5402/2011/797463
PMID:23724311
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3658845/
Abstract

The objective of the study was to estimate the prevalence of transmitted resistance to antiretroviral of HIV-1 circulating in Niger. We collected plasmas from 96 drug-naive patients followed up in the main HIV/AIDS Care Center of Niamey, the capital city of Niger. After RNA extraction and retrotranscription to proviral DNA, nested PCR was performed to amplify PR (codons 1-99) and RT (codons 1-240) fragments for sequencing. Sequences were analysed for phylogeny, then for resistance-associated mutations according to IAS-USA and Stanford's lists of mutations. We characterized six HIV-1 genetic variants: CRF02-AG (56.3%), CRF30_0206 (15.6%), subtype G (15.6%), CRF06_cpx (9.4%), CRF11_cpx (2.1%), and CRF01_AE (1%). About 8.3% of HIV strains had at least 1 resistance mutation: 4 strains with at least 1 mutation to NRTI, 5 for NNRTI, and 1 for PI, respectiveley 4.2%, 5.2%, and 1.0%. These preliminary results gave enough information for the need of instauring HIV drug resistance national surveillance.

摘要

该研究的目的是评估在尼日尔流行的HIV-1对抗逆转录病毒药物的传播耐药性患病率。我们从尼日尔首都尼亚美主要的艾滋病毒/艾滋病护理中心随访的96名未接受过抗逆转录病毒治疗的患者中采集了血浆。在进行RNA提取并逆转录为前病毒DNA后，进行巢式PCR以扩增蛋白酶（第1至99密码子）和逆转录酶（第1至240密码子）片段用于测序。对序列进行系统发育分析，然后根据IAS-USA和斯坦福大学的突变列表分析耐药相关突变。我们鉴定出六种HIV-1基因变体：CRF02-AG（56.3%）、CRF30_0206（15.6%）、G亚型（15.6%）、CRF06_cpx（9.4%）、CRF11_cpx（2.1%）和CRF01_AE（1%）。约8.3%的HIV毒株至少有1个耐药突变：4株对核苷类逆转录酶抑制剂至少有1个突变，5株对非核苷类逆转录酶抑制剂有突变，1株对蛋白酶抑制剂有突变，分别为4.2%、5.2%和1.0%。这些初步结果为开展全国性HIV耐药监测的必要性提供了足够的信息。