Zhu Yu, Zhuang Jun-Xue, Wang Qin, Zhang Hai-Yan, Yang Ping
Department of Clinical Laboratory, Tianjin Huan Hu Hospital, Tianjin, China.
Asian Pac J Cancer Prev. 2013;14(4):2607-10. doi: 10.7314/apjcp.2013.14.4.2607.
Malignant glioma, also known as brain cancer, is the most common intracranial tumor, having an extremely high mortality and recurrence rate. The survival rate of the affected patients is very low and treatment is difficult. Hence, growth inhibition of glioma has become a hot topic in the study of brain cancer treatment. Among the various isothiocyanate compounds, it has been confirmed that benzyl isothiocyanate (BITC) can inhibit the growth of a variety of tumors, including leukemia, glioma and lung cancer, both inside and outside the body. This study explored inhibitory effects of BITC on human glioma U87MG cells, as well as potential mechanisms. It was found that BITC could inhibit proliferation, induce apoptosis and arrest cell cycling of U87MG cells. In addition, it inhibited the expression of SOD and GSH, and caused oxidative stress to tumor cells. Therefore, it is believed that BITC can inhibit the growth of U87MG cells outside the body. Its mechanism may be related to the fact that BITC can cause oxidative stress to tumor cells.
恶性胶质瘤，也被称为脑癌，是最常见的颅内肿瘤，死亡率和复发率极高。患病患者的存活率很低且治疗困难。因此，抑制胶质瘤生长已成为脑癌治疗研究中的一个热门话题。在各种异硫氰酸酯化合物中，已证实异硫氰酸苄酯（BITC）在体内外均可抑制包括白血病、胶质瘤和肺癌在内的多种肿瘤的生长。本研究探讨了BITC对人胶质瘤U87MG细胞的抑制作用及其潜在机制。研究发现，BITC可抑制U87MG细胞的增殖、诱导其凋亡并使细胞周期停滞。此外，它还抑制了超氧化物歧化酶（SOD）和谷胱甘肽（GSH）的表达，并对肿瘤细胞造成氧化应激。因此，认为BITC可在体外抑制U87MG细胞的生长。其机制可能与BITC可对肿瘤细胞造成氧化应激这一事实有关。
