Sainsbury Laboratory, University of Cambridge, Cambridge, CB2 1LR, United Kingdom.
Annu Rev Phytopathol. 2013;51:383-406. doi: 10.1146/annurev-phyto-082712-102255.
Transcription activator-like (TAL) effectors are encoded by plant-pathogenic bacteria and induce expression of plant host genes. TAL effectors bind DNA on the basis of a unique code that specifies binding of amino acid residues in repeat units to particular DNA bases in a one-to-one correspondence. This code can be used to predict binding sites of natural TAL effectors and to design novel synthetic DNA-binding domains for targeted genome manipulation. Natural mechanisms of resistance in plants against TAL effector-containing pathogens have given insights into new strategies for disease control.
转录激活子样效应物（TAL）效应物由植物病原细菌编码，并诱导植物宿主基因的表达。TAL 效应物基于一种独特的密码与 DNA 结合，该密码指定重复单元中的氨基酸残基与特定 DNA 碱基的一一对应结合。该密码可用于预测天然 TAL 效应物的结合位点，并设计用于靶向基因组操作的新型合成 DNA 结合结构域。植物对含有 TAL 效应物的病原体的天然抗性机制为疾病控制提供了新的策略。
