接种疫苗中的人类树突状细胞亚群。
Human dendritic cell subsets in vaccination.
机构信息
Ralph M. Steinmann Center for Cancer Vaccines, Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX, USA.
出版信息
Curr Opin Immunol. 2013 Jun;25(3):396-402. doi: 10.1016/j.coi.2013.05.001. Epub 2013 May 30.
Abstract
Owing to their properties, dendritic cells (DCs) are often called 'nature's adjuvants' and thus have become the natural targets for antigen delivery. DCs provide an essential link between the innate and the adaptive immune responses. DCs are at the center of the immune system owing to their ability to control both tolerance and immunity. DCs are thus key targets for both preventive and therapeutic vaccination. Herein, we will discuss recent progresses in our understanding of DC subsets physiology as it applies to vaccination.
摘要
由于其特性，树突状细胞 (DC) 通常被称为“天然佐剂”，因此成为抗原递呈的天然靶点。DC 提供了先天免疫和适应性免疫反应之间的重要联系。由于 DC 能够控制耐受和免疫，因此它们处于免疫系统的中心。因此，DC 是预防和治疗性疫苗接种的关键靶点。在此，我们将讨论我们对 DC 亚群生理学的理解在疫苗接种方面的最新进展。
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