Baylor Institute for Immunology Research and INSERM U899, Dallas, TX 75204, USA.
Immunol Cell Biol. 2010 May-Jun;88(4):376-80. doi: 10.1038/icb.2010.28. Epub 2010 Mar 23.
Dendritic cells (DCs) orchestrate the innate and adaptive immune systems to induce tolerance and immunity. DC plasticity and subsets are prominent determinants in the regulation of immune responses. Our recent studies suggest that humoral and cellular immunity is regulated by different myeloid DC subsets with distinct intrinsic properties in humans. Although antibody response is preferentially mediated by CD14(+) dermal DCs, cytotoxic T-cell response is preferentially mediated by Langerhans cells (LCs). Thus, mechanisms whereby DCs induce humoral and cellular immunity seem to be fundamentally distinct. In this review, we will focus on the role of DCs in the development of humoral immunity. We will also discuss the mechanisms whereby DCs induce CD4(+) T cells associated with aiding B-cell response, including T follicular helper (Tfh) cells, and why human LCs lack this ability.
树突状细胞 (DCs) 协调先天和适应性免疫系统以诱导耐受和免疫。DC 的可塑性和亚群是调节免疫反应的突出决定因素。我们最近的研究表明，体液和细胞免疫受不同的髓样 DC 亚群调节，这些亚群具有人类内在的不同特性。虽然抗体反应主要由 CD14(+) 真皮 DC 介导，但细胞毒性 T 细胞反应主要由朗格汉斯细胞 (LCs) 介导。因此，DC 诱导体液和细胞免疫的机制似乎在根本上是不同的。在这篇综述中，我们将重点讨论 DC 在体液免疫发展中的作用。我们还将讨论 DC 诱导与辅助 B 细胞反应相关的 CD4(+) T 细胞的机制，包括滤泡辅助性 T 细胞 (Tfh)，以及为什么人类 LCs 缺乏这种能力。
