Department of Chemistry, Faculty of Specific Education, Zagazig University, Zagazig, Egypt.
Department of Eco-Physiology, Desert Research Center, Cairo, Egypt.
Nat Prod Res. 2020 Jun;34(12):1763-1771. doi: 10.1080/14786419.2018.1530234. Epub 2019 Jan 2.
Investigation of yielded five flavonoids, including aglycone flavone (apigenin), flavone glycoside (apigenin 7-O-D-glucopyranoside), new gernaylated flavone glycoside (apigenin 8-gernayl-4'-O--gluco pyranoside) and two new pernylated flavonoid glycosides & (apigenin 8-pernyl-4'-glucopyranosyl-7-O--glucopyranoside and apigenin 5-pernyl-7-glucopyranosyl-4'-O--D-glucopyranoside). Their structures were elucidated on the basis of spectroscopic evidence. The cytotoxicity of compounds - were tested against Lung adenocarcinoma (A549), human hepatocellular liver carcinoma (HepG2), human breast carcinoma (MCF-7) cell lines and mouse fibroblast cell line NIH/3T3 as normal cells. This assay gave spot on structure activity relationship which, showed that cytotoxicity of compounds ( and ( against three cell lines was weak as IC > 15. Compounds and ( had moderate cytotoxic and no toxic effect on normal cell. Compound ) showed high cytotoxic activity against tested three cell lines with no toxic effect of normal cells.[Formula: see text].
研究发现了五种类黄酮，包括苷元黄酮（芹菜素）、黄酮糖苷（芹菜素 7-O-D-吡喃葡萄糖苷）、新的香叶基化黄酮糖苷（芹菜素 8-香叶基-4'-O--吡喃葡萄糖苷）和两种新的苯丙基化黄酮糖苷（芹菜素 8-苯丙基-4'-吡喃葡萄糖基-7-O--吡喃葡萄糖苷和芹菜素 5-苯丙基-7-吡喃葡萄糖基-4'-O--D-吡喃葡萄糖苷）。它们的结构是根据光谱证据阐明的。测定了化合物-对肺腺癌（A549）、人肝癌细胞（HepG2）、人乳腺癌细胞（MCF-7）和小鼠成纤维细胞系 NIH/3T3 作为正常细胞的细胞毒性。该测定给出了关于构效关系的明确信息，表明化合物（和（对三种细胞系的细胞毒性较弱，IC>15。化合物和（对正常细胞无毒性，具有中等细胞毒性。化合物）对三种测试细胞系表现出高细胞毒性，对正常细胞无毒性作用。
