New cytotoxic flavonoids from aerial parts of L.

Investigation of yielded five flavonoids, including aglycone flavone (apigenin), flavone glycoside (apigenin 7-O-D-glucopyranoside), new gernaylated flavone glycoside (apigenin 8-gernayl-4'-O--gluco pyranoside) and two new pernylated flavonoid glycosides & (apigenin 8-pernyl-4'-glucopyranosyl-7-O--glucopyranoside and apigenin 5-pernyl-7-glucopyranosyl-4'-O--D-glucopyranoside). Their structures were elucidated on the basis of spectroscopic evidence. The cytotoxicity of compounds - were tested against Lung adenocarcinoma (A549), human hepatocellular liver carcinoma (HepG2), human breast carcinoma (MCF-7) cell lines and mouse fibroblast cell line NIH/3T3 as normal cells. This assay gave spot on structure activity relationship which, showed that cytotoxicity of compounds ( and ( against three cell lines was weak as IC > 15. Compounds and ( had moderate cytotoxic and no toxic effect on normal cell. Compound ) showed high cytotoxic activity against tested three cell lines with no toxic effect of normal cells.[Formula: see text].