Children's Health and Exercise Research Centre, Sport and Health Sciences, University of Exeter, Exeter EX1 2LU, UK.
J Cyst Fibros. 2013 Dec;12(6):644-50. doi: 10.1016/j.jcf.2013.04.012. Epub 2013 May 28.
The reproducibility of cardiopulmonary exercise testing (CPET) has not been established in young cystic fibrosis (CF) patients using a valid protocol.
Thirteen 7-18 year olds completed three CPETs, separated by 48 h and 4-6 weeks. CPET involved a ramp-incremental cycling test with supramaximal verification.
Maximal oxygen uptake was repeatedly determined with no learning effect and typical errors expressed as a coefficient of variation (TE(CV%)) of 9.3% (48 h) and 13.3% (4-6 weeks). The reproducibility of additional parameters of aerobic function [gas exchange threshold (TE(CV%): 11.2%, 16.8%); VO2 mean response time (TE(CV%): 37.8%, 89.4%); VO2 gain (TE(CV%): 17.4%, 24.5%)] and clinical utility [e.g. SaO2% (TE(CV%): 2.2%, 3.1%); ventilatory drive (V(E)/VCO2-slope) (TE(CV%): 7.8%, 17.7%)] was also established over the short- and the medium-term, respectively.
These results establish limits of variability to determine meaningful changes over the short- and the medium-term for CPET outcomes in young CF patients.
在使用有效方案的情况下，心肺运动测试（CPET）在年轻囊性纤维化（CF）患者中的可重复性尚未得到证实。
13 名 7-18 岁的患者完成了 3 次 CPET，间隔 48 小时和 4-6 周。CPET 涉及递增式踏车测试和最大验证。
最大摄氧量的多次测定无学习效应，典型误差表示为变异系数（CV%）的 9.3%（48 小时）和 13.3%（4-6 周）。有氧功能的其他参数（如换气阈（CV%）：11.2%，16.8%；VO2 平均反应时间（CV%）：37.8%，89.4%；VO2 增益（CV%）：17.4%，24.5%）和临床应用（如 SaO2%（CV%）：2.2%，3.1%；通气驱动（VE/VCO2-slope）（CV%）：7.8%，17.7%）的重复性也在短期和中期内得到了确立。
这些结果确定了短期和中期内 CPET 结果的可变性限制，以确定有意义的变化。
