Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea; Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.
Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Clin Biochem. 2013 Aug;46(12):1036-1040. doi: 10.1016/j.clinbiochem.2013.05.048. Epub 2013 May 29.
Osteoprotegerin (OPG) is a member of the tumor necrosis factor receptor superfamily and suggested as a marker of atherosclerosis. We investigated whether plasma OPG levels were associated with the presence and severity of cerebral atherosclerosis.
We used an enzyme-linked immunosorbent assay to measure the plasma OPG levels of 107 patients with acute cerebral infarction. We compared the plasma OPG levels according to the presence and number of arteries with cerebral atherosclerosis (≥ 50% stenosis).
Of 107 patients, 73 (68.2%) had cerebral atherosclerosis. OPG levels were increased in patients with cerebral atherosclerosis (374.69 ± 206.48 vs 261.17 ± 166.91 pg/mL, p=0.006). OPG levels showed positive correlation with the number of cerebral arteries with atherosclerosis (Spearman's rho=0.342, p<0.001). After adjustment for vascular risk factors, OPG>229.9 pg/mL was independently associated with the presence [OR 4.61, 95% CI 1.57-13.55, p=0.005, binary logistic regression] of cerebral atherosclerosis and number [OR 3.20, 95% CI 1.26-8.12, p=0.014, ordinal logistic regression] of arteries with cerebral atherosclerosis.
Plasma OPG levels were significantly associated with the presence and severity of cerebral atherosclerosis. This finding suggests that plasma OPG might have a role in cerebral atherosclerosis.
骨保护素（OPG）是肿瘤坏死因子受体超家族的一员，被认为是动脉粥样硬化的标志物。我们研究了血浆 OPG 水平是否与脑动脉粥样硬化的存在和严重程度有关。
我们使用酶联免疫吸附试验测量了 107 例急性脑梗死患者的血浆 OPG 水平。我们根据是否存在和存在多少条有脑动脉粥样硬化（≥50%狭窄）的动脉来比较血浆 OPG 水平。
在 107 例患者中，有 73 例（68.2%）有脑动脉粥样硬化。有脑动脉粥样硬化的患者 OPG 水平升高（374.69±206.48 比 261.17±166.91 pg/ml，p=0.006）。OPG 水平与有动脉粥样硬化的脑动脉数量呈正相关（Spearman's rho=0.342，p<0.001）。在调整血管危险因素后，OPG>229.9 pg/ml 与脑动脉粥样硬化的存在[比值比（OR）4.61，95%置信区间（CI）1.57-13.55，p=0.005，二项逻辑回归]和有脑动脉粥样硬化的动脉数量[OR 3.20，95%CI 1.26-8.12，p=0.014，有序逻辑回归]独立相关。
血浆 OPG 水平与脑动脉粥样硬化的存在和严重程度显著相关。这一发现表明，血浆 OPG 可能在脑动脉粥样硬化中起作用。
