血红蛋白与三种配体的相互作用：有机磷酸盐与玻尔效应。
Interaction of hemoglobin with three ligans: organic phosphates and the Bohr effect.
作者信息
Benesch R E, Rubin H
出版信息
Proc Natl Acad Sci U S A. 1975 Jun;72(6):2465-7. doi: 10.1073/pnas.72.6.2465.
Abstract
The assumption that the Bohy coefficient (less than log p 50)/(less than pH) is equal to the haldane coefficient (less than h minus plus) of hemoglobin is shown to be incorrect in the presence of allosteric effectors such as 2,3-diphosphoglycerate. The theoretical relation between the two coefficients in the presence of 2.3-diphosphoglycerate as derived. Experimental data on the variation of both coefficients with diphosphoglycerate concentration are presented and shown to be in agreement with prediction.
摘要
在存在诸如2,3 - 二磷酸甘油酸等变构效应剂的情况下，玻希系数（小于log p 50）/（小于pH）等于血红蛋白的霍尔丹系数（小于h负加）这一假设被证明是不正确的。推导了在存在2,3 - 二磷酸甘油酸时这两个系数之间的理论关系。给出了两个系数随二磷酸甘油酸浓度变化的实验数据，并表明其与预测结果一致。
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