1] Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA [2] Department of Pathology, University of Vermont College of Medicine, Burlington, VT, USA.
Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA.
Oncogene. 2014 May 8;33(19):2413-22. doi: 10.1038/onc.2013.194. Epub 2013 Jun 3.
Melanoma progression is typically depicted as a linear and stepwise process in which metastasis occurs relatively late in disease progression. Significant evidence suggests that in a subset of melanomas, progression is much more complex and less linear in nature. Epidemiologic and experimental observations in melanoma metastasis are reviewed here and are incorporated into a comprehensive model for melanoma metastasis, which takes into account the varied natural history of melanoma formation and progression.
黑色素瘤的进展通常被描述为一个线性和逐步的过程，其中转移发生在疾病进展的相对较晚阶段。有大量证据表明，在一部分黑色素瘤中，进展更为复杂，本质上也不那么线性。本文回顾了黑色素瘤转移的流行病学和实验观察，并将其纳入一个综合的黑色素瘤转移模型，该模型考虑了黑色素瘤形成和进展的不同自然史。
