Departments of Clinical Oncology, K1-P, Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands.
Ann Hematol. 2013 Aug;92(8):1023-32. doi: 10.1007/s00277-013-1793-2. Epub 2013 Jun 1.
Hodgkin Lymphoma (HL) survivors are at risk for adverse psychosocial events as a result from cancer diagnosis and treatment. Fatigue is one of the most frequently reported long-term symptoms and is often reported to interfere with daily life. We conducted a systematic review to determine prevalence, severity and predisposing factors of fatigue in HL survivors. A literature search was conducted up to August 2012. Twenty-two articles comparing HL survivors with norm population data met all predefined selection criteria. Prevalence rates, levels of fatigue and clinical relevance of the results were determined. Prevalence of fatigue ranged from 11-76 % in HL survivors compared to 10 % in the general population. Mean fatigue scores were 5-13 % higher compared to the normative population; these findings were clinically relevant in 7 out of 11 studies. Increasing age was associated with higher levels of fatigue in HL survivors. Treatment modality and stage of initial disease were not associated with higher fatigue levels, while comorbidities or other treatment sequelae seemed to impact on the levels of fatigue. HL survivors are at serious risk for developing clinically relevant, long-term fatigue. The impact of patient and treatment characteristics on risk of fatigue is limited. Focus for future research should shift to the role of late-treatment sequelae and psychological distress symptoms.
霍奇金淋巴瘤（HL）幸存者由于癌症的诊断和治疗，面临着不良的心理社会事件的风险。疲劳是最常报告的长期症状之一，常报告称会干扰日常生活。我们进行了一项系统综述，以确定 HL 幸存者疲劳的发生率、严重程度和易患因素。文献检索截止到 2012 年 8 月。22 篇比较 HL 幸存者与正常人群数据的文章符合所有预先设定的选择标准。确定了疲劳的发生率、疲劳程度和结果的临床相关性。与一般人群的 10%相比，HL 幸存者的疲劳发生率为 11-76%。与正常人群相比，平均疲劳评分高 5-13%；在 11 项研究中有 7 项发现具有临床相关性。年龄增长与 HL 幸存者的疲劳水平升高有关。治疗方式和疾病初始阶段与更高的疲劳水平无关，而合并症或其他治疗后遗症似乎对疲劳水平有影响。HL 幸存者有发生严重的、长期的、具有临床相关性的疲劳的风险。患者和治疗特征对疲劳风险的影响是有限的。未来研究的重点应转移到晚期治疗后遗症和心理困扰症状的作用上。
