Nakayama Takahiro, Kuru Satoshi, Kawai Mitsuru
Department of Neurology, Yokohama Rosai Hospital, Yokohama, Kanagawa, Japan.
BMJ Case Rep. 2013 May 31;2013:bcr2013009301. doi: 10.1136/bcr-2013-009301.
We showed that the shape of the thigh CT value histogram, which was reflecting muscle and fat, changed with the disease progression in a patient with Duchenne muscular dystrophy, and this shape of the histogram will employ a new analytical method. CT images of the middle part of the thigh were acquired in a patient with Duchenne muscular dystrophy once a year from 6 to 11 years of age. Regions apparently corresponding to subcutaneous fat, bone and bone marrow were manually excluded, and the CT values were calculated to prepare histograms. His motor disability was also evaluated employing Vignos functional rating scale. A single peak was noted in the muscle CT value range in the histogram at the youngest age. The muscle-to-fat ratio in muscle decreased with the worsening of his disease disability level and the peak of the histogram shifted from the muscle to the fat CT value.
我们发现，在一名杜氏肌营养不良患者中，反映肌肉和脂肪情况的大腿CT值直方图的形状会随着疾病进展而改变，且这种直方图形状将采用一种新的分析方法。对一名6至11岁的杜氏肌营养不良患者每年进行一次大腿中部CT图像采集。手动排除明显对应皮下脂肪、骨骼和骨髓的区域，计算CT值以制备直方图。还采用维格诺斯功能评定量表对其运动功能障碍进行评估。在最年幼时，直方图中肌肉CT值范围内出现单峰。随着其疾病残疾程度的加重，肌肉中的肌肉与脂肪比率下降，直方图的峰值从肌肉CT值转移到脂肪CT值。
