Smith T F, Bain R P, Schiffman G
Department of Pediatrics, Emory University School of Medicine, Atlanta, GA.
Clin Exp Immunol. 1990 Jun;80(3):339-43. doi: 10.1111/j.1365-2249.1990.tb03289.x.
We measured IgG-class antibodies to 12 pneumococcal antigens pre- and post-immunization with polyvalent pneumococcal vaccine in 31 children who had experienced chronic chest symptoms. The purpose of the study was to determine the relation of IgG subclasses, especially IgG2, to the subjects' antibody responses to bacterial polysaccharide antigens, to see if measuring IgG subclasses would predict these responses. Twenty-nine children (90%) had low or low-normal levels of one or more IgG subclasses, including 20 out of 31 (65%) with low or low-normal levels of IgG2. Children studied had a relatively poor increase in levels of antibody to 10 of the 12 pneumococcal vaccine antigens investigated. Both pre- and post-immunization antibody levels were related to pre-immune serum concentrations of IgG2. Pre-immunization antibody levels were strongly related to post-immunization levels; when post-immunization antibody levels were adjusted for pre-immunization levels by partial correlation, the correlation between anticapsular antibody level post-immunization and IgG2 was no longer significant. Thus, in children with chronic chest symptoms, levels of antibody measured at a random interval after natural exposure to these bacterial polysaccharide antigens are related to levels of IgG2 subclass, but antibody increases after vaccination appear to be affected more by other factors.
我们在31名有慢性胸部症状的儿童中，测量了用多价肺炎球菌疫苗免疫前后针对12种肺炎球菌抗原的IgG类抗体。本研究的目的是确定IgG亚类，尤其是IgG2，与受试者对细菌多糖抗原的抗体反应之间的关系，以了解测量IgG亚类是否能预测这些反应。29名儿童（90%）有一种或多种IgG亚类水平低或低正常，其中31名中有20名（65%）IgG2水平低或低正常。所研究的儿童对12种被调查的肺炎球菌疫苗抗原中的10种抗体水平的升高相对较差。免疫前和免疫后的抗体水平均与免疫前血清IgG2浓度有关。免疫前抗体水平与免疫后水平密切相关；当通过偏相关对免疫后抗体水平进行免疫前水平校正后，免疫后抗荚膜抗体水平与IgG2之间的相关性不再显著。因此，在有慢性胸部症状的儿童中，自然接触这些细菌多糖抗原后随机间隔测量的抗体水平与IgG2亚类水平有关，但疫苗接种后抗体增加似乎受其他因素影响更大。
