两个不连锁的基因座相互作用，以控制人类对B族链球菌III型抗原的免疫反应。
Two unlinked genetic loci interact to control the human immune response to type III group B streptococcal antigen.
作者信息
Pandey J P, Baker C J, Kasper D L, Fudenberg H H
出版信息
J Immunogenet. 1984 Apr;11(2):159-63. doi: 10.1111/j.1744-313x.1984.tb01051.x.
Abstract
Serum samples were collected from 30 healthy adult Caucasian volunteers before and after immunization with native type III polysaccharide of group B streptococcus. Serum antibody to this polysaccharide was measured and sera were typed for several Gm and Km(1) allotypes. A significant interactive effect of Gm(23) and Km(1) was found on immune responsiveness to native type III group B streptococcus polysaccharide antigen.
摘要
从30名健康的成年白种人志愿者身上采集血清样本，这些志愿者在接种B族链球菌天然III型多糖之前和之后均被采集样本。检测了针对该多糖的血清抗体，并对血清进行了几种Gm和Km(1)同种异型分型。发现Gm(23)和Km(1)对天然III型B族链球菌多糖抗原的免疫反应性存在显著的交互作用。
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