褪黑素用于治疗儿童和青少年的睡眠障碍。
Melatonin for the management of sleep disorders in children and adolescents.
作者信息
Cummings Carl
出版信息
Paediatr Child Health. 2012 Jun;17(6):331-6.
Abstract
Problems of sleep initiation and maintenance occur in 15% to 25% of children and adolescents. Studies of the benefits of melatonin for sleep disorders have been published for healthy populations, for children and adolescents with attention-deficit hyperactivity disorder, for children and youth with autism, and for several other special populations. These studies demonstrate benefit with minimal side effects. However, all studies have involved small numbers of subjects and address only short-term use of melatonin. There are no good data concerning the safety and efficacy of long-term melatonin use. Further studies are needed to confirm the usefulness and safety of melatonin for sleep disorders in children and adolescents.
摘要
入睡和维持睡眠问题在15%至25%的儿童和青少年中出现。关于褪黑素对睡眠障碍益处的研究已发表，涉及健康人群、患有注意力缺陷多动障碍的儿童和青少年、患有自闭症的儿童和青年以及其他几个特殊人群。这些研究表明其益处显著且副作用极小。然而，所有研究涉及的受试者数量都较少，且仅针对褪黑素的短期使用。目前尚无关于长期使用褪黑素安全性和有效性的可靠数据。需要进一步研究以证实褪黑素对儿童和青少年睡眠障碍的有效性和安全性。
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1
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Pediatr Neurol. 2010 Apr;42(4):249-54. doi: 10.1016/j.pediatrneurol.2009.11.002.
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J Am Acad Child Adolesc Psychiatry. 2009 Feb;48(2):99-107. doi: 10.1097/CHI.0b013e3181930639.
3
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J Intellect Disabil Res. 2010 Jan 1;54(1):52-9. doi: 10.1111/j.1365-2788.2009.01223.x. Epub 2009 Nov 2.
4
Complementary, holistic, and integrative medicine: melatonin.
Pediatr Rev. 2009 Jun;30(6):223-8. doi: 10.1542/pir.30-6-223.
5
Sleep disorders: causes, effects, and solutions.
Prim Care. 2008 Dec;35(4):817-37. doi: 10.1016/j.pop.2008.07.006.
6
Melatonin for chronic insomnia in Angelman syndrome: a randomized placebo-controlled trial.
J Child Neurol. 2008 Jun;23(6):649-54. doi: 10.1177/0883073808314153.
7
FPIN's clinical inquiries. Medications for insomnia treatment in children.
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8
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J Intellect Disabil Res. 2008 Mar;52(Pt 3):256-64. doi: 10.1111/j.1365-2788.2007.01016.x.
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10
A randomized, placebo-controlled trial of controlled release melatonin treatment of delayed sleep phase syndrome and impaired sleep maintenance in children with neurodevelopmental disabilities.
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