Can Fam Physician. 2020 Mar;66(3):183-185.
I have several patients with autism spectrum disorder (ASD) who experience difficulties with sleep, affecting the quality of life of both the child and the family. Is melatonin an effective treatment for sleep problems in children with this condition? Autism spectrum disorder is prevalent among children in Canada and globally, with most affected children experiencing troubles with sleep. Behavioural therapy is the first-line treatment for sleep problems in children with ASD, and melatonin has been reported to be effective and safe in this population as an alternative or adjunctive treatment. A new pediatric, prolonged-release formulation of melatonin is not yet available in Canada, but initial studies in Europe have indicated that it is a potentially effective treatment for sleep problems in children with ASD.
我有几个自闭症谱系障碍 (ASD) 的患者，他们有睡眠困难，这影响了孩子和家庭的生活质量。褪黑素是否是治疗这种情况儿童睡眠问题的有效方法？自闭症谱系障碍在加拿大和全球的儿童中很常见，大多数受影响的儿童都有睡眠问题。行为疗法是治疗 ASD 儿童睡眠问题的一线治疗方法，褪黑素已被报道在该人群中作为替代或辅助治疗是有效和安全的。一种新的儿科、缓释褪黑素配方在加拿大尚未上市，但欧洲的初步研究表明，它是治疗 ASD 儿童睡眠问题的一种潜在有效方法。
