Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
Department of Endocrinology, Odense University Hospital and Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
J Am Geriatr Soc. 2013 Jun;61(6):957-962. doi: 10.1111/jgs.12279. Epub 2013 Jun 3.
To examine the effect of strength training and testosterone therapy on mechanical muscle function and lean body mass (LBM) in aging men with low-normal testosterone levels in a randomized, double-blind, placebo-controlled 24-week study.
Randomized, double-blind, placebo-controlled.
Odense, Denmark.
Men aged 60 to 78, with bioavailable testosterone levels of less than 7.3 nmol/L and a waist circumference greater than 94 cm were randomized to testosterone (50-100 mg/d, n = 22) placebo (n = 23) or strength training (n = 23) for 24 weeks. The strength training group was randomized to addition of testosterone or placebo after 12 weeks. Subjects performed supervised strength training (2-3 sets with 6- to 10-repetition maximum loads, 3 times per week).
Testosterone levels, maximal voluntary contraction and rate of force development, and LBM were obtained at 0 and at Weeks 12 and 24 of the intervention.
No changes in any variables were recorded with placebo. In the strength training group, maximal voluntary contraction increased 8% after 12 weeks (P = .005). During the following 12 weeks of strength training rate of force development increased by 10% (P = .04) and maximal voluntary contraction further increased (P < .001). Mechanical muscle function was unchanged in men receiving only testosterone for 24 weeks. LBM increased only in men receiving testosterone (P = .004).
Strength training in aging men with low-normal testosterone levels may improve mechanical muscle function, but this effect occurs without a significant increase in LBM. Clinically, only the combination of testosterone therapy and strength training resulted in an increase in mechanical muscle function and LBM.
在一项随机、双盲、安慰剂对照的 24 周研究中，检查力量训练和睾丸激素治疗对低正常睾丸激素水平的老年男性的肌肉力学功能和瘦体重（LBM）的影响。
随机、双盲、安慰剂对照。
丹麦欧登塞。
年龄在 60 至 78 岁之间，生物可利用性睾丸激素水平低于 7.3 nmol/L，腰围大于 94 cm 的男性，被随机分为睾丸激素（50-100 mg/d，n = 22）、安慰剂（n = 23）或力量训练（n = 23）组，进行 24 周的治疗。力量训练组在 12 周后随机加入睾丸激素或安慰剂。受试者接受监督力量训练（2-3 组，每组 6-10 次重复最大负荷，每周 3 次）。
在干预的 0 周和 12 周和 24 周时，获得睾丸激素水平、最大自愿收缩和力量发展率以及 LBM。
安慰剂组没有记录到任何变量的变化。在力量训练组中，12 周后最大自愿收缩增加了 8%（P =.005）。在接下来的 12 周力量训练中，力量发展率增加了 10%（P =.04），最大自愿收缩进一步增加（P <.001）。仅接受睾丸激素治疗 24 周的男性肌肉力学功能没有变化。只有接受睾丸激素治疗的男性 LBM 增加（P =.004）。
在低正常睾丸激素水平的老年男性中进行力量训练可能会改善肌肉力学功能，但这一效果不会导致 LBM 显著增加。临床上，只有睾丸激素治疗和力量训练的结合才能增加肌肉力学功能和 LBM。
