Almoznino G, Zini A, Mizrahi Y, Aframian D J
Department of Oral Medicine, Hebrew University Hadassah School of Dental Medicine, Jerusalem, Israel; Department of Oral Medicine, Oral and Maxillofacial Center, Medical Corps, Israel Defense Forces, Tel Hashomer, Israel.
Oral Dis. 2014 May;20(4):386-94. doi: 10.1111/odi.12131. Epub 2013 Jun 4.
To characterize demographic, clinical and serological parameters in recurrent aphthous stomatitis (RAS) patients and analyse their association with serum immunoglobulin E (IgE) levels.
Forty-nine patients with RAS responded to a questionnaire that included demographic background, stress status, smoking habits, history and course of RAS episodes. They were also subjected to relevant laboratory tests, including determination of serum IgE levels.
A familial history of RAS was reported by 47.9% of the patients, stress in the previous year by 51.1% and smoking by 18.4%. Non-Caucasian origin, familial history of RAS, stress and smoking were associated with increased severity of RAS episodes. Haematological deficiencies were observed in 18.7% of RAS patients. Average IgE levels were increased and were significantly associated with younger age, ≤12 years of schooling, female gender, RAS episode frequency of every 2 weeks, early onset of RAS episodes and elevated C reactive protein levels.
Immunoglobulin E levels may be considered as part of the RAS patient's work-up. Further research is needed to identify biological mechanisms that account for the observed associations.
描述复发性阿弗他口炎（RAS）患者的人口统计学、临床和血清学参数，并分析它们与血清免疫球蛋白E（IgE）水平的关联。
49例RAS患者回答了一份问卷，内容包括人口统计学背景、应激状态、吸烟习惯、RAS发作的病史和病程。他们还接受了相关实验室检查，包括血清IgE水平测定。
47.9%的患者报告有RAS家族史，51.1%的患者报告前一年有应激情况，18.4%的患者吸烟。非白种人血统、RAS家族史、应激和吸烟与RAS发作的严重程度增加有关。18.7%的RAS患者存在血液学缺陷。平均IgE水平升高，且与年龄较小、受教育年限≤12年、女性、每2周发作一次RAS、RAS发作早发以及C反应蛋白水平升高显著相关。
免疫球蛋白E水平可被视为RAS患者检查的一部分。需要进一步研究以确定解释所观察到关联的生物学机制。
