Department of Urology, Faculty of Medicine, Mevlana University, Konya, Turkey.
J Endourol. 2013 Sep;27(9):1126-30. doi: 10.1089/end.2013.0086. Epub 2013 Aug 1.
The present study evaluates the efficiency and reliability of a hemostatic agent ABS (Ankaferd Blood Stopper(®)) in tubeless percutaneous nephrolithotomy (PCNL).
A total of 90 patients were divided into two subgroups. The first group had ABS applied during the intervention, whereas the control group underwent regular tubeless PCNL in this prospective randomized study. Age, stone size, operative time, postoperative hemoglobin change, renal parenchyma thickness, postoperative ureteral catheter removal time, access number, nephroscope time, blood transfusion rate, serum creatinine change, complication rate, visual analogue scale (VAS), and hospitalization time were compared between the two groups.
Preoperative and postoperative data obtained from both groups were compared. No statistically meaningful differences were found related to variables of mean age, stone size, access number, serum creatinine change, operative time, renal parenchyma thickness, VAS scores, and hospitalization period. Whereas the nephroscope time (minutes) was longer in the ABS group (Group 1 [G1]:3, 33±1, 72 vs G2:2, 62±1, 43, P=0.035), hemoglobin (Hb) decrease, and urine clarity time were statistically lower compared with the control group. Hb decrease was (mg/dL) (G1: 1.40±1.04 vs G2: 1.84±1.15, P=0.034), and urine clarity time was (hour) (G1: 9.60±5.50 vs G2: 11.95±4.71, P=0.012), respectively. Complications were encountered in three (6.6%) patients of the ABS group and in four (8.8%) of the control group.
ABS is an efficient and reliable hemostatic agent in tubeless PCNL. Comparative studies are needed, however, with other hemostatic agents that might be applied in tubeless PCNL.
本研究评估了一种止血剂 ABS（安可速血凝剂）在无管经皮肾镜取石术（PCNL）中的效率和可靠性。
在这项前瞻性随机研究中，90 名患者被分为两组。第一组在手术中使用 ABS，而对照组则进行常规无管 PCNL。比较两组的年龄、结石大小、手术时间、术后血红蛋白变化、肾实质厚度、术后输尿管导管拔除时间、通道数量、肾镜时间、输血率、血清肌酐变化、并发症发生率、视觉模拟评分（VAS）和住院时间。
比较了两组的术前和术后数据。两组间平均年龄、结石大小、通道数量、血清肌酐变化、手术时间、肾实质厚度、VAS 评分和住院时间等变量均无统计学意义。然而，ABS 组的肾镜时间（分钟）较长（组 1 [G1]：3.33±1，72 与 G2：2.62±1，43，P=0.035），血红蛋白（Hb）下降和尿液清亮时间与对照组相比统计学上较低。Hb 下降（mg/dL）（G1：1.40±1.04 与 G2：1.84±1.15，P=0.034），尿液清亮时间（小时）（G1：9.60±5.50 与 G2：11.95±4.71，P=0.012）。ABS 组有 3 例（6.6%）和对照组有 4 例（8.8%）发生并发症。
ABS 是无管 PCNL 中一种有效且可靠的止血剂。然而，需要与可能应用于无管 PCNL 的其他止血剂进行比较研究。
