Simsek Cem, Selek Sebnem, Koca Meltem, Haznedaroglu Ibrahim Celal
Department of Internal Medicine, Hacettepe University, Ankara, Turkey.
Icericumra Health Care System, Konya, Turkey.
SAGE Open Med. 2017 Jul 27;5:2050312117722569. doi: 10.1177/2050312117722569. eCollection 2017.
Ankaferd blood stopper is a standardized mixture of the plants , , , , and and has been used as a topical hemostatic agent and with its clinical application established in randomized controlled trials and case reports. Ankaferd has been successfully used in gastrointestinal endobronchial mucosal and cutaneous bleedings and also in abdominal, thoracic, dental and oropharyngeal, and pelvic surgeries. Ankaferd's hemostatic action is thought to form a protein complex with coagulation factors that facilitate adhesion of blood components. Besides its hemostatic action, Ankaferd has demonstrated pleiotropic effects, including anti-neoplastic and anti-microbial activities and tissue-healing properties; the underlying mechanisms for these have not been well studied. Ankaferd's individual components were determined by proteomic and chemical analyses. Ankaferd also augments transcription of some transcription factors which is shown with transcriptomic analysis. The independent effects of these ingredients and augmented transcription factors are not known precisely. Here, we review what is known of Ankaferd blood stopper components from chemical, proteomic, and transcriptomic analyses and propose that individual components can explain some pleiotropic effects of Ankaferd. Certainly more research is needed focusing on individual ingredients of Ankaferd to elucidate their precise and effects.
安卡菲德止血剂是植物、、、和的标准化混合物，已被用作局部止血剂，其临床应用已在随机对照试验和病例报告中得到确立。安卡菲德已成功用于胃肠道、支气管内膜、皮肤出血，以及腹部、胸部、牙科、口咽和盆腔手术。安卡菲德的止血作用被认为是与凝血因子形成一种蛋白质复合物，促进血液成分的黏附。除了其止血作用外，安卡菲德还表现出多种效应，包括抗肿瘤和抗菌活性以及组织愈合特性；其潜在机制尚未得到充分研究。通过蛋白质组学和化学分析确定了安卡菲德的各个成分。转录组分析显示，安卡菲德还增强了一些转录因子的转录。这些成分和增强的转录因子的独立作用尚不清楚。在这里，我们回顾了从化学、蛋白质组学和转录组学分析中了解到的安卡菲德止血剂成分，并提出单个成分可以解释安卡菲德的一些多效性效应。当然，还需要更多的研究聚焦于安卡菲德的单个成分，以阐明它们的确切作用和效果。
