Rikihisa Y, Lin Y C, Garber P L, Gu Y
Department of Veterinary Pathobiology, College of Veterinary Medicine, Ohio State University, Columbus 43210.
Exp Parasitol. 1990 Aug;71(2):135-45. doi: 10.1016/0014-4894(90)90016-6.
Gossypol, a natural biphenyl compound inhibits Taenia taeniaeformis metacestode development in vivo. In this paper, the direct effect of gossypol on metacestodes was examined. Within 24 hr of incubation at 37 degrees C in greater than or equal to 10(-5) M gossypol, shedding of the tegument from the surface of the metacestodes was observed. There was a significant decrease in [3H]thymidine uptake by T. taeniaeformis in greater than or equal to 10(-5)M gossypol. In addition, NADH lactate dehydrogenase activity of metacestodes was significantly inhibited in greater than or equal to 10(-5) M gossypol. Thus, gossypol has a direct inhibitory effect on T. taeniaeformis metacestodes in vitro.
